Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors. Int J Cancer. 2010; 127:899-909. [PubMed: 20013807]Van Dongen M, Savage ND, Jordanova ES, Briaire-de Bruijn IH, Walburg KV, Ottenhoff TH, Hogendoorn PC, van der...
Moreover, ES-Exos or ESCs increased M2 macrophages and anti-inflammatory cytokine, IL-10. Additionally, ES-Exos or ESCs treatment inhibited significantly cytoplasmic vacuolization, myofibril loss, hypertrophy, and improved heart function. In conclusion, for the first time we demonstrated that Dox-...
Meanwhile, HO-1 has anti-inflammatory effects and can regulate various immune cells [20], which is related to the polarization of macrophages. The HO-1 can induce the transformation of macrophages from M1 to M2 type, and convert macrophages into anti-inflammatory type [88]. In the body, ...
26. This notion is corroborated by reports indicating that an ever-growing array of hematopoietic cell types can promote both angiogenesis and immunosuppression, which include M2 alternatively activated macrophages, tumor-associated macrophages27, Tie...
Adiponectin enhances cold-induced browning of subcutaneous adipose tissue via promoting M2 macrophage proliferation. Cell Metab. 22, 279–290 (2015). Article CAS PubMed Google Scholar Fujisaka, S. et al. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. ...
hEPCs compose myeloid cells as well such as M2 macrophages, the latter has strong anti-inflammatory effect21,22. In addition, ECFCs possess a remarkable ability to integrate into existing vascular networks and contribute to endothelial repair and regeneration. By directly replacing damaged endothelial...
The immunoregulation of macrophages polarization toward M2 phenotype that facilitates the transition from inflammation to proliferation phase has been proved to be an effective way to improve diabetic wound healing. Herein, an M2 phenotype-enabled anti-inflammatory, antioxidant, and antibacterial conductive ...
Macrophages are divided into type I macrophages (M1) and type II macrophages (M2). As pro-inflammatory macrophages, M1 macrophages play important role in the pathogenesis of AIDs (Zhai et al., 2016). Macrophage infiltration was a notable pathological change in ConA-induced liver and kidneys inju...
During placental development, the previous dominance of M1-macrophages is succeeded by a more anti-inflammatory M2-milieu7. M2-macrophages secrete IL-10 and Transforming growth factor (TGF)-β and promote tissue-healing8. The M2-milieu continues into the second and third trimester with anti-inflam...
Macrophages play pivotal roles in the progression and regression of atherosclerosis. Accumulating evidence suggests that macrophage polarization into an anti-inflammatory M2 state is a key characteristic of atherosclerotic plaques undergoing regression.