Antibodies associated with BCMA, antigen binding fragments and conjugates (e.g., drug drug conjugation (ADC), such as including splicing regulators) are disclosed. The present disclosure further relates to methods and compositions for use in the treatment of cancer by administering compositions ...
Belantamab mafodotin-blmf is an antibody-drug conjugate (ADC). The antibody component is an afucosylated IgG1 directed against B-cell maturation antigen (BCMA), a protein expressed on normal B lymphocytes and multiple myeloma cells. The small molecule component is MMAF, a microtubule inhibit...
#应用#客户文献解读|双抗+ADC组合拳:三阴性乳腺癌“新克星” 产品详情 公司简介 公司评价 资质证书 手机查看 手机查看 一键电话致商家 抗体名: Research Grade Anti-Human CD269/TNFRSF17/BCMA (HDP-101) 亚型: IgG 浓度: 1mg/ml % 是否单克隆: 是 靶点: HDP-101 免疫原: Human 宿主: 是 ...
Results: As of June 1, 2022, 20 patients (13-ADC exposed; 7 BsAb exposed; 1 patient in the ADC group also had prior BsAb exposure) were treated with cilta-cel. Four patients did not receive cilta-cel due to either low cellular yield (n=2, 1 patient in each group) or death due ...
This disclosure relates to methods of treating cancers in a human patient (e.g., Multiple myeloma (MM)) comprising administration of an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against B-cell maturation antigen (BCMA) ...
Background: HDP-101 is a novel antibody-drug conjugate (ADC) that targets B-cell maturation antigen (BCMA) with a synthetic amanitin payload, which inhibits RNA polymerase II. This action effectively halts transcription and induces apoptosis in tumor cells, regardless of their proliferation status....
#应用#客户文献解读|双抗+ADC组合拳:三阴性乳腺癌“新克星” #动态#性激素|“不务正业”的跨界高手 产品详情 公司简介 公司评价 资质证书 手机查看 手机查看 一键电话致商家 抗体名: Research Grade Anti-Human CD269/TNFRSF17/BCMA (PRG1801) 亚型: IgG 浓度: 1mg/ml % 是否单克隆: 是 靶点: ...
COMBINATION THERAPIES USING AN ANTI-BCMA ANTIBODY DRUG CONJUGATE (ADC) IN COMBINATION WITH A GAMMA SECRETASE INHIBITOR (GSI)The present disclosure relates to methods of using antibody conjugates with binding specificity for BCMA (BCMA) and its isoforms and homologs in combination with a gamma ...
When the same four samples were targeted with a BCMA antibody drug conjugate (ADC), 3 of the samples gave EC50 values of 1.25卤0.7 nM (mean 卤 SD) - i.e. a 43 fold decrease in potency compared to the CD3 bispecific. The fourth patient did not respond to the ADC. Together, these ...