2024年9月19日,于君教授团队在Cancer Cell上发表了题为Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer的研究论文。该研究提示了,Fn丰度可能是预测微卫星稳定型结直肠癌中anti-PD-1治...
Parisi, L. Robert, A. Ribas, Anti-PD-1 therapy in melanoma, Semin. Oncol. 42 (2015) 466-473, doi:http://dx.doi.org/10.1053/j. seminoncol.2015.02.008.Homet Moreno B, Parisi G, Robert L, Ribas A. Anti-PD-1 therapy in melanoma. Semin Oncol 2015;42:466-73....
PD-1表达于多种肿瘤组织中的肿瘤浸润型淋巴细胞, 包括头颈部癌、黑色素瘤和非小细胞肺癌(non-small-cell lungcancer, NSCLC)通过靶向PD-1的免疫治疗可以克服肿瘤环境的免疫抑制、重新激活患者自身的免疫细胞来杀伤肿瘤, 进而治疗多种癌症。尽管肿瘤免疫治疗在一些患者身上取得了显著且持久的疗效, 但PD-1治疗的患者...
2023年11月02日,哥伦比亚大学爱尔文医学中心的研究人员在Cancer Cell期刊发表了题为:Anti-PD-1immunotherapywith androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer的研究文章。 与其他恶性肿瘤相比,原发性和去势抵抗性前列腺癌(CRPC)的肿瘤微环境(TME)相对...
近日，来自加州大学洛杉矶分校的Antoni Ribas 团队在Nature 上发表题为Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy 的文章。该文章建立了发现肿瘤抗原特异性T细胞的方法，并对比了抗PD-1治疗有反应和无反应患者的CD8+T细胞中针对肿瘤抗原的TCR类型。作者认为在分析免疫检查点阻断剂（immune ...
高精尖创新中心(ICG)张泽民课题组联合301医院韩为东课题组在国际期刊Nature Cancer上发表了题为Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer的研究论文,提出了克隆复兴(clonal revival)的概念并揭示了PD-1抗体治疗在肺癌...
(ICG)张泽民课题组联合301医院韩为东课题组在国际期刊Nature Cancer上发表了题为“Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer”的研究论文,提出了克隆复兴(clonal revival)的概念并揭示了PD-1抗体治疗在肺癌中的作用...
Caroline Robert, MD, PhD, discusses the role of adjuvant anti–PD-1 therapy in resected stage IIB/IIC melanoma based on findings from the KEYNOTE-716 and CheckMate 76K trials. This is a modal window. The Playback API request failed for an ...
Programmed death 1 expression in cancer and infection: tissue versus periphery PD-1:PD-L1 blockade as host-directed therapy Anti-PD-1:PD-L1/2 therapy: improved efficacy with acceptable toxicity Anti-PD-1 versus anti-PD-L1/2 therapy and opportunities for combination with other immunotherapies Conc...
高精尖创新中心(ICG)张泽民课题组联合301医院韩为东课题组在国际期刊Nature Cancer上发表了题为Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer的研究论文,提出了克隆复兴(clonal revival)的概念并揭示了PD-1抗体治疗在肺癌...