Disclosed is an isolated or purified T cell receptor (TCR) with antigen specificity for a mutant Kirsten rat sarcoma virus oncogene homolog (KRAS) presented in the context of the HLA-Cw * 0802 molecule . Related polypeptides and proteins, as well as related nucleic acids, recombinant expression...
Oncogene-directed increased expression of Nrf2 is a mechanism for the activation of the Nrf2 antioxidant program evident in primary cells and tissues of mice expressing KRas(G12D) and BRaf(V619E), and in human pancreatic cancer. 研究类别 1. Chan, J. Y., Cheung, M.-C., Moi, P., ...
Anti RAS(A146T) Mouse Monoclonal Antibody 产品信息 RAS(A146T) [26261][100ul] Catalog Number: 26261 Gene Symbol: HRas; KRas; NRas Description: Anti RAS(A146T) Mouse Monoclonal Antibody Background: The A146T mutation of KRas results in an amino acid substitution at position 146, from ...
Under high oxidative stress conditions within the tumor microenvironment, pancreatic ductal adenocarcinoma (PDAC) tumor cells secrete the KRAS G12D protein, which in turn stimulates fatty acid oxidation in macrophages and facilitates their polarization towards the M2-type through the STAT3 pathway [27]....
Oncogenic RAS mutants are key anti-cancer targets as KRas mutations are very frequent in human cancers. Here, the authors engineer a cytosol-penetrating anti-Ras antibody and demonstrate its ability to block RAS-effector protein interactions inhibiting tumour growth of Ras mutant-driven cancers. 展开...
confirmed that CRAF, not BRAF, was essential for tumor initiation by resident KRASG12D oncogenes in non-small cell lung carcinoma. Interestingly, while BRAF has been proposed as the primary ERK activator due to its higher kinase activity [77], knock-out of BRAF and/or CRAF did not impact...
All PDAC PDX tumors contained G12D mutations in KRAS as determined by PCR sequencing as described in [24]. To establish low-passage primary PDX-derived in vitro cultures, PDX tumors were minced, enzymatically digested with collagenase (Stem Cell Technologies) for 60 min at 37°C, clarified ...
In order to explore the mechanism by which KRASG12D leads to defects in mitosis, we treated H2B-GFP- expressing HeLaG12D cells with doxycycline for 24 h, then added two different MEK1/2 inhibitors: the first-generation compound, U0126, and the highly potent and selective inhibitor, AZD...
Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats Article Open access 18 March 2020 Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen Article Open access 10 September 2022 Int...
HH-gene-237 pEGFP-KRAS(G12D)哺乳动物表达K-Ras的蛋白质粒 HH-gene-236 pCMV-KRAS(G12A)哺乳动物表达K-Ras的蛋白质粒 HH-gene-235 pEGFP-KRAS(G12A)哺乳动物表达K-Ras的蛋白质粒 HH-gene-218 pCMV-KRAS(G12C) 哺乳动物表达K-Ras的蛋白质粒 HH-gene-217 pCMV-KRAS 哺乳动物表达K-Ras的蛋白质粒 HH-...