OVA-sensitized mice were treated with anti-IL4Rα-conjugated nanoparticles. The levels of pro-inflammatory cytokines in the lungs and broncho-alveolar lavage fluid (BALF) were determined using a cytokine array assay. The effects of nanoparticle treatment on the activation of lung inflammatory cells ...
An attractive alternative is inhibition of multiple proinflammatory mediators and induction of immunoregulatory activity by regulatory cytokines such as IL4 and IL10. Many studies demonstrated the strong capacity of IL4 and IL10 as stand-alone drugs to inhibit inflammation and tissue-destructive ...
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Drugs used for the prevention and treatment of allergic diseases are called as antiallergic agents. Such kinds of drugs include: 1. anti-histamine drug which mainly includes histamine H1 receptor antagonists, such as promethazine, diphenhydramine, etc., it can compete with histamine to bind to...
Table (4). Anti-inflammatory drugs in T2D. DrugsMechanism of actionMain findingsSide EffectsReferences Anakinra IL-1 receptor blockade studies on their use in the prevention of atherosclerosis and CVD have HbA1c, leukocyte ↓, CR↓ insulin secretion↑, insulin requirement ↓, and Insulin sensitivity...
Clone NYRmIL-4. Immunogen r.Murine IL-4. Ig Subclass Rat IgG1. Purification Method Ion exchange. Protein concentration 1mg/ml in PBS (after reconstitution). Shipping Conditions Antibody is shipped lyophilized at ambient temperature. Storage Procedures In lyophilized form, for long periods,...
the risk of the development of resistance and the incidence of certain side effects in the host organism can be assessed, though it is currently possible only to a moderate extent to derive a proposal for a useful combination therapy on the basis of the mode of action of the drugs in quest...
IL: Interleukin IL-1Ra: IL-1 receptor antagonist NF-κB: Nuclear factor-κB NSAIDs: Nonsteroidal anti-inflammatory drugs RA: Rheumatoid arthritis TNF-α: Tumor necrosis factor-α UGIB: Upper gastrointestinal bleeding References Download references ...
Moreover, the anti-tumor treatment of TCM formulas are also involved in following ways: (1) inhibiting of tumor cell invasion and metastasis, (2) reversing drug resistance, (3) increasing the efficacy of chemotherapy, (4) alleviating side effects of chemotherapy drugs, (5) regulating immune ...
without relying on protease-cleavable technology or mutagenesis of cytokine to abrogate off-tumor activity associated with significant toxicity of the majority of cytokines from this class of drugs. The high preclinical efficacy observed in monotherapy and good tolerance profile of the first two drug ca...