Profacgen provides well recognized anti-drug antibody evaluation service with advanced technology platform and a variety of assay formats that can help accelerate your drug development project.
Antibody Custom Services suitable for ADA assay OptionsAntibody typesTimeEpitopeCharacteristicsRemark 1Affinity purified rabbit pAb10-12 weeksMultipleGood specificity; High sensitivity; Low cost; Short-time; Batch variationRecommended 2Mouse mAb26-29 weeksSingleHigh specificity; Minimal batchvariation; Lower ...
Provided is an immunoassay for detection of anti-drug antibodies (ADAs), such as anti-C1-lnhibitor antibodies (C1 INH-ADA) in a test sample. The immunoassay provides a means for testing the immunogenicity and efficacy of drug treatment protocols. The immunoassay comprises the steps of (i) ...
antibody, characterized in that the capture drug antibody is a mixture of said drug antibody conjugated to the solid phase at least two different antibody sites and the tracer drug antibody is a mixture of said drug antibody conjugated to the detectable label at least two different antibody sites...
Anti-drug antibody assay 优质文献 相似文献 参考文献Anti-drug antibody assays The invention provides an antibody binding specifically to Cynomolgus IgG characterized by not binding to Human IgG, and a method for the immunological determination of an immune complex (DA/ADA complex) of a drug antibody...
• Antibody drug binding assay • Human IgG binding assay • antigen-competitive interventional assays Vector construction (1-2 weeks) Sequencing and vector construction production & QC analysis (2-3 weeks) • Recombinant expression • Protein A purification • SDS-PAGE and UV analysis ...
Relevant advances have been made in the management of relapsed/refractory (r/r) Hodgkin Lymphomas (HL) with the use of the anti-CD30 antibody–drug conjugate (ADC) brentuximab–vedotin (Bre–Ved). Unfortunately, most patients eventually progress despite the excellent response rates and tolerability...
影响抗体药物ADA(Anti-Drug antibody)产生的因素mp.weixin.qq.com/s/VZidrEghK9gCUusOKK1K4g 之后,为了降低免疫原性,先后开发了嵌合体抗体,人源化抗体和全人源单抗。虽然免疫源性比全鼠源降低,但依然会产生抗药物抗体(ADA)。 经典抗体药物ADA发生率及检测方法(文献1) ADA形成的影响因素 ADA的产生有两种机...
CD103 mediates T-cell infiltration and organ allograft rejection, and depletion of CD103-expressing cells is a promising therapeutic strategy for allograft intolerance. Recently, we verified that M290-MC-MMAF, an anti-CD103 antibody-drug conjugate, potently eliminates CD103-positive cells in vivo,...
Evolving immunogenicity assay performance expectations and a lack of harmonized anti-drug antibody validation testing and reporting tools have resulted in