The traditional basis for the identification of living organisms usually requires their isolation and growth in the laboratory. Reliance on these parameters have limited our awareness of the role of bacteria in the pathophysiology of diseases. PCR tests are used to detect the genetic signature of bac...
if an antibody to a low-prevalence antigen is detected in the serum of a pregnant woman, identification of the antibody or determination of its reactivity with paternal RBCs is required to predict the likelihood and severity of HDN in the baby. Locating blood for exchange transfusion is not dif...
Identification of single antigen-specific ASCs presents a considerable challenge—target cells secreting antibodies with desirable properties have to be selected from a vast pool of cells producing nonspecific binders while maintaining the link between the phenotype of the secreted antibody and the cell t...
Assay precision using DBS samples Assay precision was determined using DBS from negative whole blood and a panel of low, middle, and high positive DBS samples. The DBS panel was prepared by diluting anti-HCV positive plasma spiked into negative whole blood and diluted at 1:20, 1:100, 1:200...
O. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. J. Biol. Chem. 276(29), 27371–27375 (2001). 16. Crawford, A., et al., A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer. Sci. Transl. Med., 2019....
In addition, this scheme was extended to monkeys, where staining with CD31 and CD45 led to the identification of the FcγRIIB-expressing population, and to reveal concentration-dependent binding and uptake of the antibody. This assay is expected to be used for determining PK parameters and ...
et al. (1987) “Flow Cytometric Analysis of Human Bone Marrow: I. Normal Erythroid Development” Blood, vol. 69, No. 1, pp. 255-263. Simmons, P.J. et al. “Identification of Stromal Cell Precursors In Human Bone Marrow by a Novel Monoclonal Antibody, STRO-1” Blood (1991), vol....
Bates GJ, Fox SB, Han C, Leek RD, Garcia JF, Harris AL, Banham AH: Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J Clin Oncol. 2006, 24: 5373-5380. 10.1200/JCO.2006.05.9584. Article PubMed Google...
between the IGHV1-2∗02 segment and the 3′ homology arm to serve as the positive selection marker for transfection; the neomycin selection marker is flanked with two loxP sites to effect the removal of the drug selection marker subsequent to the identification of the correctly targeted clones...
Rapid identification of biological warfare agents using an instrument employing a light addressable potentiometric sensor and a flow-through immunofiltration-enzyme assay system. Biosens. Bioelectron. 2000, 14, 761-770. 112. Meyer, M.H.F.; Krause, H.J.; Hartmann, M.; Miethe, P.; Oster, J...