CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, ...
Function: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Ge...
Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which ...
CYP24A1 encoding for 25-hydroxyvitamin D3-24-hydroxylase, which catalyzes the fast degradation of calcitriol, was overexpressed in stem cell-like glioma cells (SLCs) under acidosis and was accounted for their stemness and metabolism changes. Hu et al. revealed that calcitriol could repress stem...
Vinclozolin is a pesticide with antiandrogenic activity as an endocrine disruptor compound. Its effects upon the progression of primordial follicles were assessed in cultures of mouse fetal ovaries from the onset of meiotic differentiation of germ cells
and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. The ALDH1A2 protein belongs to the aldehyde dehydrogenase family ...
期刊名称:《Anti-cancer agents in medicinal chemistry》 | 2009年第1期 关键词: Antineoplastic Agents; Humans; Organic Chemicals; Protein Kinase Inhibitors; 抗肿瘤药; 有机化学品; 58.Role of oxygen in cancer: looking beyond hypoxia. 机译:氧气在癌症中的作用:超越缺氧状态。 作者:Lopez Lazaro M ...
although they must be used with caution in patients with pre-existing cardiovascular disease, congenital long QT syndrome, and in those receiving concomitant QTc prolonging drugs or that inhibit the cytochrome P450 (CYP450), which is the main enzyme responsible for the metabolism of vorinostat and ...
In the nucleus, ATRA binds to retinoic acid receptor (RAR) and activates RAR-responsive genes such as TP53, which promotes the expression of p53. ATRA-induced expression of ARF promotes the expression of p14, which is a negative regulator of mouse double minute 2 (MDM2), the key inhibitor ...
This review based on translational research predicts that the transcription factor p53 is the key effector of all anti-acne therapies. All-trans retinoic acid (ATRA) and isotretinoin (13-cis retinoic acid) enhance p53 expression. Tetracyclines and macrol