When neuroblastoma SK-N-BE is incubated with retinoic acid, cell body shape is modified, long neurites are formed and cell growth is inhibited (1,8). Retinoic acid is an activator of the peroxisome proliferator-
Because RXR is an essential partner of many nuclear receptors, RA can regulate the function of other nuclear receptors such as peroxisome proliferator activate receptor and farnesoid x receptor. This allows RA to regulate lipid metabolism (Bushue & Wan, 2010; Chen, Wang, & Wan, 2010; Dai et ...
a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage S Carrera1, S Cuadrado-Castano2,5, J Samuel1, GDD Jones3, E Villar2, SW Lee4 and S Macip*,1 Stra6 is the retinoic acid (RA)-inducible gene encoding the cellular receptor for holo-retinol binding ...
Previously, we reported that the differentiation of another subset of TGF-β–driven T helper cells, Th17 cells, is highly dependent on de novo lipid biosynthesis. On the basis of these findings, we hypothesized that lipid metabolism may also be important for Th9 cell differentiation. We ...
[87,88]. FXR can recognize free or conjugated bile acid and thus acts as an intracellular sensor of bile acid to regulate the metabolism of bile acid in the liver. Activation of liganded-FXR/RXR promotes bile acid efflux and inhibits bile acid synthesis [89]. PPAR is a lipid sensing ...
melan-a data set show that RA "normalized" the expression of genes involved in energy metabolism, DNA replication, DNA repair and differentiation. These results are compatible with the known growth inhibitory and pro-differentiating effects of RA. Pathway analysis suggests that CDC2, CHEK1, CDC45L...
suggesting that they each have particular functions. Another level at which fine tuning of retinoid action could occur is the metabolism of vitamin A to active metabolites, which may include all-trans-retinoic acid4–7, all-trans-3,4-didehydroretinoic acid8, 9-cis-retinoic acid9,10, and 14...
产品活性:Retinoic acid 是维生素A的代谢产物,在细胞生长,分化和器官发生中起重要作用。 Retinoic acid是RAR核受体的天然激动剂,对RARα/β/γ的IC50为14 nM。 Retinoic acid与PPARβ/δ结合的Kd值为17 nM。Retinoic acid 可以通过激活视黄酸受体抑制转录因子 Nrf2。
1. Retinoic acid--a player that rules the game of life and death in neutrophils [J] . Kapil Mehta Indian Journal of Experimental Biology . 2002,第8期 机译:维甲酸-统治嗜中性粒细胞生死博弈的参与者 2. Cell death in Poriferai molecular players in the game of apoptotic cell death in ...
Schwann cell migration is essential during the regenerative response to nerve injury, however, the factors that regulate this phenomenon are not yet clear. Here we describe that retinoic acid (RA), whose production and signaling activity are greatly enhanced during nerve regeneration, increases Schwann...