When neuroblastoma SK-N-BE is incubated with retinoic acid, cell body shape is modified, long neurites are formed and cell growth is inhibited (1,8). Retinoic acid is an activator of the peroxisome proliferator-activating receptors and RA receptor may regulate fatty acid homeostasis (4). More...
Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity Retinoic acid-related orphan receptors RORα and RORγ play a regulatory role in lipid/glucose homeostasis and various immune functions, and have been impl... AM Jetten...
The toxicity of OMVs can be reduced by deleting the lipid A modification gene msbB, htrB, or combined msbB and pagP [131–134]. Another method to reduce the toxicity of OMVs is to pre-treat them with all-trans retinoic acid, active metabolite of vitamin A, which has both anti-inflammator...
27,28,29], the role of lipid metabolism in Th9 cell differentiation remains largely unclear. To address this gap in the literature, we examined the role of lipid metabolism in Th9 cell differentiation and function in vitro in mouse and human cells and in ...
The effects of retinol (vitamin A alcohol), retinoic acid (vitamin A acid), and beta-carotene (pro-vitamin A) on human interferon (HuIFN) action were examined in vitro. Retinoic acid and beta-carotene, at concentrations in or near the physiologic range, were consistently found to behave as...
Vitamin A is involved in the regulation of cardiovascular risk factors like glucose concentration, lipid metabolism, and inflammation6. Two forms of biologically active metabolites of retinoic acid (RA): all-trans-retinoic acid (ATRA) and 9-cis retinoic acid (9-cis RA), regulate a wide variety...
The retinoic acid receptor-related orphan receptor (ROR) alpha has been demonstrated to regulate lipid metabolism. We were interested in the RORα1 depende... S Raichur,RL Fitzsimmons,SA Myers,... - 《Nucleic Acids Research》 被引量: 119发表: 2010年 Retinoic acid induces adult muscle cell ...
FXR can recognize free or conjugated bile acid and thus acts as an intracellular sensor of bile acid to regulate the metabolism of bile acid in the liver. Activation of liganded-FXR/RXR promotes bile acid efflux and inhibits bile acid synthesis [89]. PPAR is a lipid sensing nuclear receptor...
a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage S Carrera1, S Cuadrado-Castano2,5, J Samuel1, GDD Jones3, E Villar2, SW Lee4 and S Macip*,1 Stra6 is the retinoic acid (RA)-inducible gene encoding the cellular receptor for holo-retinol binding ...
It has been postulated that cytoplasmic retinoic acid binding proteins: (i) act as a buffer by sequestering retinoic acid in the cytoplasm and preventing excess ligand from reaching the nucleus, (ii) carry and present retinoic acid to different enzyme systems for metabolism, thus reg...