In addition, vitamin A-deprived but retinoic acid-supplemented male rats exhibit hypogonadism and infertility due to lack of local retinoic acid synthesis in the testis; similar treatment of female rats causes infertility due to fetal resorption caused by a lack of local retinoic acid synthesis in ...
Function of retinoid acid recep- tor alpha and p21 in all-trans-retinoic acid-induced acute T-lymphoblastic leukemia apoptosis. Leuk Lymphoma 2009; 50:1183-1189.Luo P, Lin M, Lin M, Chen Y, Yang B, He Q. Function of retinoid acid receptor alpha and p21 in all- trans -retinoic acid-...
Crowe, D.L.; Osaseri, U.E.; Shuler, C.F. Tumor suppressor function of a dominant negative retinoic acid receptor mutant. Mol. Carcinog. 1998, 22, 26-33. [CrossRef]Crowe DL, Osaseri UE, Shuler CF. Tumor suppressor function of a dominant negative retinoic acid receptor mutant. Mol ...
The contribution of retinoic acid (RA) to Treg differentiation is well described39,40,41,42. Therefore, it is plausible that isotretinoin, as a RA derivate, might also influence T-cell fate. The role of specific microRNAs in T helper (Th) cell differentiation has been well documented, e.g...
Retinoic acid signaling Retinoic acid (RA) is known to regulate murine endothelial cell development and specification [73,74]. Biologically active retinoic acid, known as all-trans retinoic acid (ATRA), is derived from retinol (Vitamin A) via oxidation by retinaldehyde dehydrogenases (RALDH1-3)....
Topoisomerase II beta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance McNamara S,Wang H,Hanna N,et al.Topoisomerase Ilbeta negatively modulates retinoic acid receptor alpha function:a novel mechanism of retinoic acid resistance... McNamara S,...
Advances in molecular biology and retinoic acid receptor research have significantly contributed to the understanding of the role of vitamin A during vertebrate development. Examination of the function of this vitamin during very early developmental stages using the completely vitamin A-depleted avian embry...
Both the cytoplasmic and nuclear classes of retinoid-binding proteins are expressed early in development and are proposed to control the concentration of retinoic acid and the transcription of retinoid-responsive genes, respectively. Given the profound effects of retinoic deficiency or excess on the ...
2002. The anti-estrogenic effect of all- trans-retinoic acid on the breast cancer cell line MCF-7 is dependent on HES-1 expression. J Biol Chem. ... Muller,P. - 《Journal of Biological Chemistry》 被引量: 169发表: 2002年 All-trans retinoic acid (ATRA) upregulates thrombomodulin and do...
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