PROBLEM TO BE SOLVED: To provide an antibody-drug conjugate (ADC) and ADC derivatives for the treatment of CD70-expressing cancer and immunological disorders.SOLUTION: Anti-CD70 antibody combined with cytotoxic agent, immune suppressor or other therapeutic agents, and derivative of the same, and ...
An anti-CD70 antibody drug conjugate developed by Ambrx, Inc. has been administered to the first patient in a Phase I study in China. It marks the first ADC in active development that targets CD70.
An anti-CD70 antibody drug conjugate developed by Ambrx, Inc. has been administered to the first patient in a Phase I study in China. It marks the first ADC in active development that targets CD70.
Anti-CD70-ADC (CD70-ADC) Anti-cMET ADC (CBT-161) Anti-endosialin-MC-VC-PABC-MMAE Anti-ETBR (RG-7636) anti-HER-3 ADC anti-TEM-1 Antibody-Drug Conjugate (TEM-1-ADC). Anti-TM4SF1 ADC Aprutumab ixadotin | BAY 1187982 AR-001 | YBL-001 ARX305 ARX517-PSMA-ADC | ARX517 ARX788...
据不完全统计,目前全球处在临床研发阶段的ADC药物大概有150余种。Anti-CD19 ADC药物Loncastuximab Tesirine(简称Lonca)已于2021年4月获FDA批准上市,同时获得NCCN指南推荐,用于治疗接受过2线或2线以上系统治疗的成年R/R DLBCL患者。这是毒性载荷为Pyrrolobenzodiazepine(PBD)的第一款上市ADC药物,PBD二聚体可造成DNA...
Thermo-life PA531979 ANTI-CDADC1 EA ￥3,478.00 EA Thermo-life PA531981 ANTI-ACOT12 EA ￥3,478.00 EA Thermo-life PA531982 ANTI-FAM116A EA ￥3,478.00 EA Thermo-life PA531983 ANTI-MRPL39 EA ￥3,478.00 EA Thermo-life PA531985 ANTI-ZNF513 EA ￥3,478.00 EA Thermo-life PA531986 ANTI...
Thermo-life PA521943 ANTI-CD27L (CD27L (CD70)) EA ￥3,613.00 EA Thermo-life PA521944 ANTI-PLATELET FACTOR 4 VARIANT 1 ￥3,613.00 1 Thermo-life PA521945 ANTI-IL-1F9 EA ￥3,613.00 EA Thermo-life PA521947 ANTI-INTERLEUKIN-24 EA ￥3,613.00 EA Thermo-life PA521949 ANTI-NKG2-A ...
Thermo-life PA521869 ANTI-ADCK4 EA ￥3,613.00 EA Thermo-life PA521870 ANTI-PIK3R3 EA ￥3,613.00 EA Thermo-life PA521871 ANTI-LIM KINASE 2 EA ￥3,613.00 EA Thermo-life PA521877 ANTI-NLK EA ￥3,613.00 EA Thermo-life PA521879 ANTI-PASK EA ￥3,613.00 EA Thermo-life PA521882 ANTI...
Thermo-life PA518019 ANTI-CYBR/PSCDBP EA ￥3,478.00 EA Thermo-life PA518021 ANTI-RP6-213H19.1 EA ￥3,478.00 EA Thermo-life PA518025 ANTI-MARK4 EA ￥3,478.00 EA Thermo-life PA518026 ANTI-SWAP70 EA ￥3,478.00 EA Thermo-life PA518028 ANTI-AIBZIP/CREB3L4 EA ￥3,478.00 EA Thermo-...
Thermo-life PA525756 ANTI-ADCY10 EA ￥3,613.00 EA Thermo-life PA525757 ANTI-PPARG EA ￥3,613.00 EA Thermo-life PA525766 ANTI-TAC1 EA ￥3,613.00 EA Thermo-life PA525767 ANTI-ADSSL1 EA ￥3,613.00 EA Thermo-life PA525768 ANTI-CLDN12 EA ￥3,613.00 EA Thermo-life PA525770 ANTI-SLC...