It has been over three decades since anthracyclines took their place as the standard chemotherapy backbone for breast cancer in the curative setting. Though the efficacy of anthracycline chemotherapy is not debatable, potentially life-threatening and long-term risks accompany this class of agents, ...
38,39,40(N = 4859) showed a benefit in both DFS and OS with the use of an anthracycline (Supplementary Table1B). These studies differed in their inclusion of LN+ or LN− disease, the inclusion of HR+ or HR− breast cancer, allowance of endocrine therapy...
Experimental evidence suggests that anthracyclines, widely used in cancer chemotherapy, may impair kidney function. We assessed kidney function by serum creatinine, urinary N-acetyl-β-D-glucosaminidase activity indices (NAGi) and microalbuminuria (MA) in 160 serum and urine samples obtained from 66 ch...
Anthracyclines technically are also antibiotics, although their high toxicity precludes their use as such. Mechanism of actionAnthracyclines inhibit DNA and RNA synthesis by intercalating between base pairs of the DNA/RNA strand, thus preventing the replication of rapidly-growing cancer cells. ...
Anthracycline cardiotoxicity is an important prognostic determinant in childhood cancer survivors (CCSs). That has been reported to improve with early therapeutic inter... Y Hosono,K Takahashi,S Shigemitsu,... - European Heart Journal - Cardiovascular Imaging 被引量: 0发表: 2022年 加载更多...
While the increased rates of survival in childhood cancers have increased progressively in recent decades, many childhood cancer survivors will have at least one chronic health condition within 40 years of age. In this regard, cardiovascular complications have emerged as a leading cause of long-term...
F25 Anthracyclines in elderly cancer patient: a SIOG expert position paper A taskforce of the International Society of Geriatric Oncology (SIOG) has recently sub-mitted recommendations on the use of an-thracyclines in elderly pati... Etienne,C G.,Brain - 《Critical Reviews in Oncology/hematology...
a class ofantibioticsisolated from cultures ofStreptomycespeucetius;it includes the antineoplasticagentsdaunorubicinanddoxorubicin. The use of these drugs is limited by a chronic, cumulative, dose-related toxicity resulting in irreversiblecongestiveheart failure. ...
The results of recent clinical trials have shown that docetaxel (Taxotere; Rhne-Poulenc Rorer, Antony, France), like paclitaxel (Taxol; Bristol-Myers Squibb Oncology, Princeton, NJ), has high levels of activity in patients with anthracycline-resistant breast cancer. Agents that are at least part...
Cardiotoxicity of breast cancer treatment: no easy solution for an important long-term problem Anthracyclines are among the most active agents for the treatment of breast cancer; their use in combination regimens improves both disease-free and overall survival in patients with breast cancer. Unfortunate...