Although, the DOAC use becomes extensive in the clinical area especially cardiology, many drug drug interactions occur when DOACs are used with other drugs. Also, the safety profile of DOACs is still to be investigated. Animal models can be used to investigate the drug drug ...
Key Words. Drug Development - Animal models - Historical aspects In the post-World War II years, along with the many other resurgent scientific developments of that golden age, the pharmaceutical industry developed techniques for the mass animal screening of compounds for potential use as drugs. ...
Löscher W: Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Seizure ... H Klitgaard,A Matagne,Y Lamberty - 《Epilepsy Research》 被引量: 131发表: 2002年 Critical re-evaluation of previous preclinical strategies...
Abdul Q.Khan, ...ShahabUddin, inAnimal Models in Cancer Drug Discovery, 2019 3Various types of animal models Theanimal modelis a conceptually developed model used to explore the structural and functional dynamics in humans. The model can be explanatory (used to explain the mechanism underlying ...
- 《Drug Design Development & Therapy》 被引量: 8发表: 2017年 The Oncopig Cancer Model as a Complementary Tool for Phenotypic Drug Discovery Suitable animal models are crucial for the continued validation and discovery of new drugs, as compounds displaying promising results in phenotypicin vitro...
Animal models of disease are an indispensable tool to study the mechanisms of human disease development, as well as for drug screening and efficacy evaluations. Accurate disease animal models can accelerate the development of new drugs. To provide the highest-quality models to researchers, Cyagen con...
animal models still remains the effective one in understanding the complex etiology and multi-systemic interactions present in diabetes [26]. Many of the diabetes trials are performed in rodents while some studies are also done in larger animals. The experimental animal used in the study of diabete...
Animal models are increasingly used to study immunogenicity of therapeutic proteins. They are employed as predictive tools to assess different aspects of immunogenicity during drug development and have become vital in studying the mechanisms underlying immunogenicity of therapeutic proteins. However, the use...
Examples of animal models used in biomedical research include rodent models and nonhuman primate models. Rodent models have been extensively employed for genetic studies and disease modeling, particularly in research on cancer and neurological disorders. Rodents’ genetic similarity to humans, coupled with...
Chemical drugs usually have a wider spectrum of use, being useful for different IPN forms with a similar mechanism of action. Clear examples have been already described above, such as the development of drugs targeting the UPR and tested in mouse models of gain-of-function CMT1B (Mpz) and ...