Jansen-Olesen I, Tfelt-Hansen P, Olesen J. Animal migraine models for drug development: status and future perspectives. CNS Drugs. 2013; 27(12):1049-1068.Jansen-Olesen, I., Tfelt-Hansen, P., & Olesen, J. (2013). Animal migraine models for drug development: status and future ...
Gaunt: Animal Models in Drug Development 95 In the uproar all professional for-profiteers were unceremoni ously eliminated from the program - most of us before we could even get our hands on a dollar. I do not know how nor when the iron curtain was cracked. Evidently, however, the ...
canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must re...
Animal models in developmental therapeutics 来自 Semantic Scholar 喜欢 0 阅读量: 20 作者:SN Khleif,GA Curt 摘要: The process of discovery in cancer developmental therapeutics may begin with either empiric screening or rational drug design. In either case, the necessary steps in drug development ...
The use of functional brain imaging to quantify drug actions in the human CNS is developing rapidly and may provide powerful new techniques to filter active new drugs of the future from those that are less promising. 展开 关键词: Keywords depression behavior functional imaging animal models drug...
Depression pathogenesis remains poorly understood, and the disorder is often treatment-resistant and recurrent, necessitating the development of novel therapies, models and concepts in this field. Areas covered: Animal models are indispensable for translational biological psychiatry, and markedly advance the...
Novel targets need in vivo validation, and candidate therapeutics require appropriate preclinical platforms on which to define potential efficacy and target engagement before advancement to clinical development. We propose that ±-synuclein (±-syn)-based mammalian models will be crucial for this process...
breast cancer drug developmentmurine metastatic modelDespite massive expenditures in research and development to cure breast cancer, few agents that pass preclinical trials demonstrate efficacy in humans. Although this endeavor relies on murine models to screen for efficacy before progressing to clinical ...
Cell and small animal models for phenotypic drug discovery The phenotype-based drug discovery (PDD) approach is re-emerging as an alternative platform for drug discovery. This review provides an overview of the var... M Szabo,S Svensson Akusjärvi,A Saxena,... - 《Drug Design Development ...
As the development of antibacterials is frequently cited as an illustration of the necessity of using intact animal models in drug development, we also examine the impact this position has had on drug development in general. The development of antibacterials, and drugs in general, is placed in ...