Background: The Center for Drug Evaluation and Research through the Office of Compliance (OC) has requested that the Division of Pharmaceutical Analysis (D... W Letter,C Mail - 《Archive.hhs.gov》 被引量: 111发表: 1991年 The effect of varying the nicotine content of cigarettes on human sm...
Part of this problem may be related to insufficient training of investigators regarding A&A in laboratory animals [2]. For example, there is a common myth among some researchers assuming anesthesia is equivalent to analgesia. Accordingly, some papers may report using a hypnotic drug (pentobarbital)...
This review describes the changing use of tumour models in rodents (predominantly mice) as employed over the last four decades in anti-cancer drug discovery, and the refinements in the experimental methods used. Such models are required to examine the complexities of cancer biology (e.g. tumour...
The purpose of drug development is to find new safe, effective drugs of high quality and stability to cure diseases and save lives. Developing a new drug is a very complex process, but it can be divided intopreclinical researchand clinical studies of a new drug. Preclinical research is the ...
Background: The Academy of Managed Care Pharmacy has recently created guidelines for the submission of pharmacoeconomic models. Although these guidelines provide a general framework for the integration of pharmacoeconomic models in the drug selection process, amore disease-specific and practical 'hands-on...
Null models for the effect of combination therapies are widely used to evaluate synergy and antagonism of drugs. Due to the relevance of null models, their suitability is continuously discussed. Here, we contribute to the discussion by investigating the
DeepChem aims to provide a high quality open-source toolchain that democratizes the use of deep-learning in drug discovery, materials science, and quantum chemistry. DeepChem is a package developed by the Pande group at Stanford and originally created by Bharath Ramsundar. Table of contents: Requir...
Ongoing studies in many species seek to understand the origins, architecture and consequences of phenotypic variation under normal and dysfunctional conditions, with the aim of identifying targets for intervention that can prevent, stabilize or reverse d
Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition with high glucose level in the blood plasma resulting
Drugs and medication: This model understands when a user is asking for information about the type or brand of a drug. It invokes a scenario that presents information about the drug in question. Which models should you use? Different models use different language recognition methods. Each method ...