Peripheral:Fluorescence occurs at the edges of the nucleus in a shaggy appearance. Anti-DNA and anti-nuclear envelope antibodies cause this pattern. Seen in systemic lupus erythematosus. Speckled:Speckled fluorescence due to an antibody directed against different nuclear antigens. This pattern is common...
In addition to the titer, the test may also report the localization pattern for the antibody observed under a microscope, which can provide insights into potential autoimmune conditions. Common patterns include homogeneous, speckled, and nucleolar, each associated with different diseases. It's important...
Speckled: Fine and coarse speckles of ANA staining are seen throughout the nucleus. This pattern is more commonly associated with antibodies to extractable nuclear antigens. This pattern can be associated with Systemic Lupus Erythematosus, Sjögren’s syndrome, Systemic Sclerosis, Polymyositis, and Rh...
Background The clinical significance of Dense Fine Speckled (DFS) pattern Anti-nuclear antibodies (ANA) by indirect immunofluorescence method (IIF) is unclear and has been inversely associated with rheumatic disease 1 2.Objectives Our purpose was to determine associations between DFS pattern ANA and ...
The presence of ANA with a homogeneous & speckled (HS) pattern was significantly associated with the absence of cancer (p < 0.01). Patients with a HS pattern were found to have a lower relative risk (RR 0.7, 95%CI 0.5-0.9) of having cancer compared to those with other patterns. Can ...
The “true Speckled” antinuclear antibody (ANA) pattern: Its tumultuous history☆Author links open overlay panelThomas K. Burnham 1, D'Anne M. Kleinsmith 1Show more Add to Mendeley Share Cite https://doi.org/10.1016/0049-0172(83)90001-XGet rights and contentAccess through your organization ...
The prevalence of ANA in this population was 61.5%, mostly in lower titers (1:160 in 45.0%, 1:320 in 31.9%, 1:640 in 20.3% and 1:1280 in 2.7%). Dense fine speckled pattern was by far the most common cellular staining pattern (79.1%). A suspicion of SARD was the reported reason...
2007. Relevance of the immunofluorescence pattern for interpretation of the ANA test: the case of the dense fine speckled pattern. Rev Assoc Med Brasil 53: 439-445.Dellavance A; Leser PG,Andrade LE; Relevance of the immunofluorescence pattern for interpre tation of the ANA test-the case of ...
Figure 1 shows a conventional algorithm that could be used for this purpose. When a positive ANA result is obtained on HEp-2 cells, further studies are necessary to identify the specific autoantibodies responsible of the IIF pattern, such as anti-dsDNA or anti-ENA antibodies. While a positive...
The “true Speckled” antinuclear antibody (ANA) pattern: Its tumultuous history☆Author links open overlay panelThomas K. Burnham 1, D'Anne M. Kleinsmith 1Show more Add to Mendeley Share Cite https://doi.org/10.1016/0049-0172(83)90001-XGet rights and content...