The EP3 receptor is expressed in several classes of central and peripheral neurons. To determine the key site of EP3 receptor action in influenza-induced sickness, we obtained mice with an allele (Ptger3flox) for Cre-dependent knockout of thePtger3gene14, which encodes the EP3 receptor. We ...
Fig. 2: The rs1921622 A allele is associated with lower soluble ST2 level. a, Manhattan plot showing genetic variants at the IL1RL1 locus that are associated with plasma sST2 level, as identified by a GWAS of plasma sST2 levels in Chinese_cohort_1. Horizontal lines indicate the suggestive...
The mutations in these genes are considered highly “penetrant,” meaning a high proportion of individuals carrying a particular variant (allele or genotype) of this gene will also express the associated trait (phenotype). For example, if a particular gene or gene mutation has an 85 percent ...
it has now been shown that medullary carcinoma of the colon shows MSI with loss of the DNA mismatch repair (MMR) enzymes, such as MLH-1, MSH-2, MSH-6 and PMS-2 [13]. It is also now known that this molecular signature is shared by the more common...
The tokogenetic history of an allele or gene copy, from a particular gene, is termed a gene genealogy or gene lineage. Figure 19.3D and E illustrate a gene lineage showing the transfer of a unique mutation from parent to offspring in sexual and asexual systems, respectively. Individual gene ...
Estimating allele age. population geneticslinkage disequilibriumgene genealogyThe age of an allele can be estimated both from genetic variation among different copies (intra-allelic ... M Slatkin,B Rannala - 《Annu Rev Genomics Hum Genet》 被引量: 432发表: 2000年 加载更多来源...
2021). Conventional PCAs cannot deal with missing entries in the SNP matrix, which are common in ddRAD studies such as the one presented here. Missing data are usually imputed based on the allele frequencies observed either in that specific sampling location or in the total sample (Eaton and ...
Further analyses using external software (e.g. Merlin) are integrated as web services. Quality checks are implemented in IGS: a pedigree check, a test for Hardy Weinberg equilibrium and an allele frequency test. The pedigree check identifies offspring alleles that do not occur in the parents. ...
Myeloid cells are known to suppress antitumour immunity1. However, the molecular drivers of immunosuppressive myeloid cell states are not well defined. Here we used single-cell RNA sequencing of human and mouse non-small cell lung cancer (NSCLC) lesions,
CRISPR/Cas9 genome editing was used to make targeted point mutations inHcfc1andRonin(Fig.1). TheHcfc1c.344 C>T (p.A115V) allele is an alanine to valine substitution at amino acid position 115, which is a highly conserved residue among vertebrates (Fig.1a–d). Furthermore, this mutat...