By definition, antisense oligonucleotides (AONs) are substantially complementary (i.e. antisense) to their target, allowing them to bind to the corresponding pre-mRNA molecule. On the basis of mechanism of action, two main classes of antisense oligonucleotide can generally be discerned: (a) the ...
To evaluate the role of complex alleles, with two or more mutations in cis position, of the cystic fibrosis transmembrane conduc- tance regulator (CFTR) gene in the definition of the genotype-phenotype relationship in cystic fibrosis (CF), and to evaluate the functional significance of the highly...
Notably all three algorithms depend on the comprehensive definition of alleles (and suballeles especially for Astrolabe and Aldy) to avoid ambiguous calls and miscalls. Indel-defined star alleles are a major challenge for all three algorithms especially where the core SNV occurred in a repeat region...
Plant breeding begins with the analysis and definition of problems and weaknesses of the current germplasm, the establishment of program goals, and the definition of specific breeding objectives. The next step is selection of germplasm that possess the traits to meet the program goals. The goal is...
Eysenk HJ (1987) The definition of personality disorders and the criteria appropriate for their description. J Personal Disord 1:211–219 Google Scholar Gonda X, Juhasz G, Laszik A, Rihmer Z, Bagdy G (2005) Subthreshold depression is linked to the functional polymorphism of the 5HT transpo...
2 Hegele RA, Ginsberg HN, Chapman MJ et al: The polygenic nature of hypertriglycer- idaemia: implications for definition, diagnosis, and management. Lancet Diab Endo- crinol 2014; 2: 655–666. 3 Surendran RP, Visser ME, Heemelaar S et al: Mutations in LPL, APOC2, APOA5, GPIHBP1...