鉴别诊断: 本次分享病例为肺局灶淀粉样变性,沉积物主要为免疫球蛋白kappa轻链(图5-1) 图5-1本次病例的免疫组化:λ(左),κ(右) 由于本例出现了许多浆细胞,而免疫组化检测结果又提示具有kappa轻链限制性,因此需要鉴别的疾病主要是MALT淋巴...
There is no cure. Patients have an average life expectancy of about 1 to 1 1/2 years from the time of diagnosis. However, with successful treatment a patient's life may be extended up to an average of 6 years.Megan Rose Igno
本次分享病例为肺局灶淀粉样变性,沉积物主要为免疫球蛋白kappa轻链(图5-1) 图5-1本次病例的免疫组化:λ(左),κ(右) 由于本例出现了许多浆细胞,而免疫组化检测结果又提示具有kappa轻链限制性,因此需要鉴别的疾病主要是MALT淋巴瘤及各类浆细胞肿瘤。由于淀粉样变性与淋巴瘤的鉴别具有一定难度,因此下文中笔者主要...
鉴别诊断: 本次分享病例为肺局灶淀粉样变性,沉积物主要为免疫球蛋白kappa轻链(图5-1) 图5-1本次病例的免疫组化:λ(左),κ(右) 由于本例出现了许多浆细胞,而免疫组化检测结果又提示具有kappa轻链限制性,因此需要鉴别的疾病主要是MALT淋巴瘤及各类浆细胞肿瘤。由于淀粉样变性与淋巴瘤的鉴别具有一定难度,因此下文...
produces abnormal plasma cells. These abnormal plasma cells normally produce antibodies, also called immunoglobulins. These antibodies are an essential part of the immune system that protects the body from infection. They are composed of four protein chains: two light chains, either kappa or lambda,...
Kappa light chain-associated Fanconi's syndrome: molecular analysis of monoclonal immunoglobulin light chains from patients with and without intracellular ... Plasma cell dyscrasias may be responsible for Fanconi's syndrome, due to the toxicity of a free monoclonal kappa light chain toward kidney ...
The light chains of primary amyloidosis are predominantly lambda, in contrast to the kappa light chains seen in LCDD. Light chain deposition disease presenting as cholestatic jaundice: a case report Changes in serum free light chain rather than intact monoclonal immunoglobulin levels predict outcome fol...
Amyloidosis occurred most frequently in patients with IgG myeloma (67%), (OR = 1.98), was more often found in patients with kappa light chain versus lambda, respectively 67% and 33%. The probability of amyloidosis in patients with clinical stage III was 1.5 times higher (p = 0.05) than ...
AL蛋白(amyloid-proteinlightchainderived,AL)是一种来源于单克 隆免疫球蛋白轻链或其部分片段异常结构蛋白质,分子量5000～16000Da,可 随尿排出。最常见的轻链成分为轻链的Lamda(λ)型,少数为Kappa(κ)型,前 者大约是后者的2倍。研究发现,并非轻链的所有片段均有相同的致淀粉纤维 ...
colonoscopy revealed multiple ulcerations. Submucosal hematoma with kappa light chain deposition was later confirmed on biopsy. As a result, the authors suggest that amyloidosis with colonic involvement should be considered in patients presenting with certain uncommon yet specific GI symptoms (eg, hemato...