Mitochondrial alterations near amyloid plaques in an Alzheimer’s disease mouse model. J. Neurosci. 2013, 33, 17042–17051. [Google Scholar] [CrossRef] [PubMed] Trushina, E.; Nemutlu, E.; Zhang, S.; Christensen, T.; Camp, J.; Mesa, J.; Siddiqui, A.; Tamura, Y.; Sesaki, H....
In the group of individuals of 51 years and below, mature (neuritic) plaques are seen in the iCJD group, but not in age-matched prion diseases of different aetiology. Only in the cohort comprising much older individuals is there an increase of cortical mature plaques. d, e, Semi...
Corpora amylacea (arrows) stain blue in H&E (A) and brown in methenamine-silver (B) stain which also reveals a few senile plaques of diffuse type (B). Diffuse plaques do not contain amyloid. The patient was 104-year old female suffering from vascular dementia. Original magnification x 200...
Through injection of human Alzheimer's disease (AD) brain extracts containing pathological tau protein into transgenic mouse lines harboring different levels of amyloid plaque burden, the authors find that the presence of amyloid plaques modifies endogen
Here, we report the first comprehensive and comparative \\{IHC\\} evaluation of pyroGlu-3 Aβ deposition in humans and animal models. PyroGlu-3 Aβ immunoreactivity (IR) is abundant in plaques and cerebral amyloid angiopathy of \\{AD\\} and Down syndrome patients, colocalizing with general...
Prion protein (PrP) has been localized to amyloid-beta (Aβ) senile plaques in aging and Alzheimer disease, but it is unknown whether PrP is directly invol... K Schwarze-Eicker,K Keyvani,N Görtz,... - 《Neurobiology of Aging》 被引量: 176发表: 2005年 A novel approach to the ide...
Alzheimer disease is a major cause of cognitive failure, and a pathogenically related but more subtle process accounts for many cases of mild memory symptoms in older humans. Insoluble fibrillar plaques of amyloid β-proteins (Aβ) and neurofibrillary deposits of hyperphosphorylated tau proteins are...
Dolphins stranded on the beaches of Florida and Massachusetts show in their brains amyloid plaques, a hallmark in human beings of Alzheimer's disease, together with an environmental toxin produced by cyanobacterial blooms.
Aβ also forms deposits in the brains of a variety of mammals, including all aged non-human primates studied to date. The sequence of Aβ in these animals is identical to that in humans. No Aβ deposits have been found in the brains of wild-type rats and mice, suggesting that the ...
Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer’s disease Introduction Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly. The brains of patients with AD are characterized by an abundance of amyloid-β (Aβ) plaques and ...