Plaques are characteristic of respective pathological conditions; examples include dental plaque, amyloid proteins in Alzheimer's disease, psoriatic skin lesions, and atherosclerotic plaque. As plaques accumulate during disease progression, they tend to become semi-hardened over time and disrupt the elastici...
Mak, et al., “Polyclonals to b-amyloid (1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum, ” Brain Research, 667:138-142 (1994). Mann, et al., “Amyloid β protein (Aβ) depostion in chromosome 14-linked Alzheimer's disease. Predominance of A...
The first descriptions of AD pathology were based on silver staining (Figure 3A) without no idea about the biochemical composition (Figure 3B) or relationship to amyloid of such structures (Figure 3C,D). Plaque amyloid however was discovered relatively soon (in 1927, see previously) by Divry ...
One remarkable hallmark of all extracellular amyloids is the presence of certain cofactors that are almost invariably codeposited as a nonfibrillar component of the plaque.doi:10.1016/S1877-184X(09)70052-8Todd E. GoldeBlue Books of Neurology...
Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies examining plaque-associated proteins have shown these additional proteins are important; they provide insight into the factors that drive amyloid plaque development
The centiloid project: standardizing quantitative amyloid plaque estimation by PET. Alzheimer’s & Dement. 2015;11:1–15 e4. Article Google Scholar Lowe VJ, Lundt ES, Senjem ML, Schwarz CG, Min H-K, Przybelski SA, et al. White matter reference region in PET studies of 11C-pittsburgh...
plaque structures. However, these studies are, as all microscopy techniques, limited by the diffraction laws that set a size limit in the micrometer range. Even though new super-resolution techniques have pushed this limit towards the nanometer range, it is still not possible to derive molecular...
plaque structures. However, these studies are, as all microscopy techniques, limited by the diffraction laws that set a size limit in the micrometer range. Even though new super-resolution techniques have pushed this limit towards the nanometer range, it is still not possible to derive molecular...
Amyloidosis can be divided into two groups, namely localized amyloidosis and systemic amyloidosis, according to the accumulation sites of protein plaque deposition. Localized amyloidosis primarily occurs in one specific tissue or organ, such as IAPP amyloids in the extracellular space of pancreatic beta ...
Alzheimer’s disease (AD) is the most common neurodegenerative disorder leading to progressive cognitive decline with pathological hallmarks of senile plaque and neurofibrillary tangle formation in the brain. In 1984, Glenner & Wong discovered that the amyloid β protein (Aβ) is the central componen...