The invention describes the formation of amyloid plaques by coincubation of an amyloid protein with sulfated macromolecules such as perlecan. The resulting plaques may be stained with congo red and demonstrate a maltese-cross pattern when viewed under polarized light. Alternatively the plaques may be...
Amyloid-β (Aβ) plaques and α-synuclein (α-syn)-rich Lewy bodies are the major neuropathological hallmarks of Alzheimer's disease (AD) and Parkinson's disease, respectively. An overlap of pathologies is found in most individuals with dementia with Lewy bodies (DLB) and in more than 50...
amyloid fibrilssuper-resolution imagingcharge transfernear infrared(NIR)emissionThe formation of amyloid plaques usually occurs in the early-stage of Alzheimer's disease (AD).Stimulated emission depletion (STED) imaging provided a powerful tool for visualizing... 查看全部>>...
Fibrils composed of amyloid beta-peptide, serum amyloid A, amylin and prion protein share beta-sheet structure and are characteristic of the extracellular pathology of amyloidoses, such as Alzheimer's disease, systemic amyloidosis, and prion disease. Abundant accumulations of fibrils observed late in...
A characteristic feature of Alzheimer's disease (AD) is the formation of amyloid plaques in the brain. Although this hallmark pathology has been well described, the biological effects of plaques are poorly understood. To study the effect of amyloid plaques on axons and neuronal connectivity, we ...
Amyloid plaques are the pathological hallmark of Alzheimer Disease (AD) brains, being found primarily in the hippocampus and neocortex, where AD pathology is most evident. Complement activation is associated with amyloid plaques which are made from fibrils of aggregated amyloid peptides, 39–42 amino...
n addition to opening the door for better IAPP inhibitors in type-2 diabetes, the findings provide potentially important insights into the formation and treatment of amyloid plaques in Alzheimer’s disease, Parkinson’s disease, and other conditions, the researchers say. ...
These diseases are all characterized by the propagation of infectious prions and, in many instances, the formation of amyloid plaques4–6, which are mainly composed of insoluble, protease-resistant form of prion protein (PrPSc). And it is reported that the PrPSc shares the identi- cal primary ...
These results help rationalize a wide range of previous fragment and mutation studies including mutations in other species that prevent the formation of amyloid plaques. 展开 关键词: POLYPEPTIDE IAPP AMYLIN FIBRILS SOLID-STATE ISLET PROTEIN AGGREGATION SPECTROSCOPY FIBRILLOGENESIS IDENTIFICATION INHIBITOR ...
Crucially, by understanding the roles of microglia and infection in Aβ amyloid fibril assembly it may be possible to identify new therapeutic targets for Alzheimer's disease. 展开 关键词: Microglia Infection amyloid plaques amyloid fibril Aβ β-Amyloid Azheimer’s disease ...