The invention describes the formation of amyloid plaques by coincubation of an amyloid protein with sulfated macromolecules such as perlecan. The resulting plaques may be stained with congo red and demonstrate a maltese-cross pattern when viewed under polarized light. Alternatively the plaques may be...
protein–induced multimerization of the amyloid precursor protein may be another mechanism by whichamyloid ? protein contributes to synapse loss and neuronal cell death seen in Alzheimer’s disease.Ann Neurol 2003;54:781–789The accumulation of amyloid ? (A?) protein withinplaques in brain is ...
Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome. Arch Pathol Lab Med. 2001;125(4):489–92. CAS PubMed Google Scholar Gouras GK, Almeida CG, Takahashi RH. Intraneuronal Abeta accumulation and origin of plaques in Alzheimer’s disease. Neurobiol Aging. ...
Experimental Induction of β-Amyloid Plaques and Cerebral Angiopathy in Primatesa (but no spongiform encephalopathy) were also found in the brain of a marmoset inoculated with brain tissue from a patient with priori disease with ... HF Baker,RM Ridley,LW Duchen,... - 《Annals of the New Yor...
Amyloid plaques are the pathological hallmark of Alzheimer Disease (AD) brains, being found primarily in the hippocampus and neocortex, where AD pathology is most evident. Complement activation is associated with amyloid plaques which are made from fibrils of aggregated amyloid peptides, 39–42 amino...
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the presence of Amyloid-β plaques in the brain. Although the causal relationship between these protein fibrillar aggregates and the neurodegenerative disease has not been established yet, the ‘amyloid hypothesis’, that accumulat...
Amyloid fibrils result from the aggregation of host cell-encoded proteins, many giving rise to specific human illnesses such as Alzheimer’s disease. Here we show that the major virulence factor of Rift Valley fever virus, the protein NSs, forms filamentous structures in the brain of mice and ...
International Journal of Molecular Sciences Article Indomethacin Disrupts the Formation of β-Amyloid Plaques via an α2-Macroglobulin-Activating lrp1-Dependent Mechanism Pei-Pei Guan, Liu-Qing Yang, Guo-Biao Xu and Pu Wang * College of Life and Health Sciences, Northeastern University, Shenyang ...
Epidemiologic evidence implicates cyclooxygenase activity in the pathogenesis of Alzheimer's disease, in which amyloid plaques have been found to contain increased levels of dimers and higher multimers of the amyloid β peptide. The product of the oxygenation of arachidonic acid by the cyclooxygenases,...
Alzheimer's disease (AD) is the most common cause of dementia. A characteristic feature of AD is the presence of amyloid plaques in the cortex and hippocampus of the brain. The principal component of these plaques is the amyloid-? (A?) peptide, a cleavage product from proteolytic processing...