Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. Cell Metab. 19, 630–641 (2014). 148. Otera, H. et al. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J....
AMPK/OPA1信号通路大鼠目的探讨丹参保心茶(Danshen Baoxin Cha)对冠心病合并认知功能障碍大鼠的影响.方法将雄性SD大鼠随机分为正常组和模型复制组.模型复制组大鼠双侧脑室注射链脲佐菌素(STZ)造认知功能障碍模型,皮下注射盐酸异丙肾上腺素(ISO)造心肌缺血模型.通过行为学实验验证心肌缺血模型及认知功能障碍造模成功后,将...
图三:PNS-R1恢复IL-13诱导的MMP丢失,减少HNEPCs细胞凋亡。 为了了解PNS-R1在IL-13诱导的线粒体功能障碍中的调节作用,作者检测了线粒体分裂蛋白(Drp1和Fis1)和融合蛋白(MFN2、MFN1和OPA1)的表达,以及Drp1在线粒体上的易位。如图所示,Drp1...
图三:PNS-R1恢复IL-13诱导的MMP丢失,减少HNEPCs细胞凋亡。 为了了解PNS-R1在IL-13诱导的线粒体功能障碍中的调节作用,作者检测了线粒体分裂蛋白(Drp1和Fis1)和融合蛋白(MFN2、MFN1和OPA1)的表达,以及Drp1在线粒体上的易位。如图所示,Drp1...
为了了解PNS-R1在IL-13诱导的线粒体功能障碍中的调节作用,作者检测了线粒体分裂蛋白(Drp1和Fis1)和融合蛋白(MFN2、MFN1和OPA1)的表达,以及Drp1在线粒体上的易位。如图所示,Drp1的总蛋白质丰度没有显著变化。然而,IL-13刺激增加了Drp1中Ser616的磷酸化,减弱了Drp1中Ser637的磷酸化,表明Drp1被激活。IL-13刺激...
147. Mishra, P., Carelli, V., Manfredi, G. & Chan, D. C. Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. Cell Metab. 19, 630–641 (2014). 148. Otera, H. et al. Mff is an essential factor for mitochondrial ...
Optic atrophy 1 (OPA1)‐related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1‐related mitochondrial fusion/mitophagy is activated by melatonin and, consequently, attenuates cardiomyocyte death and mitoc...
147. Mishra, P., Carelli, V., Manfredi, G. & Chan, D. C. Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. Cell Metab. 19, 630–641 (2014). 148. Otera, H. et al. Mff is an essential factor for mitochondrial ...
为了了解PNS-R1在IL-13诱导的线粒体功能障碍中的调节作用,作者检测了线粒体分裂蛋白(Drp1和Fis1)和融合蛋白(MFN2、MFN1和OPA1)的表达,以及Drp1在线粒体上的易位。如图所示,Drp1的总蛋白质丰度没有显著变化。然而,IL-13刺激增加了Drp1中Ser6...