AMP-activated protein kinase (AMPK)signaling in endothelial cells is essential for angiogenesis in response tohypoxic stress.J Biol Chem. 2003;278:31000 –31006 [13 ]Shaw R J, KosmatkaM,Bardeesy N, et a1. The tumor supp ressor LKB1 kinase directly activatesAMPKactivated kinase and regulates ...
Insulin-stimulated GLUT4 translocation is impaired in people with type 2 diabetes. In contrast, exercise results in a normal increase in GLUT4 translocatio... Musi,Fujii,M F,... - 《Diabetes》 被引量: 578发表: 2001年 AMP-activated Protein Kinase (AMPK) Signaling in Endothelial Cells Is ...
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507–511 (2017). This study, together with reference 83, demonstrates that small-molecule AMPK activators can restore insulin sensitivity and reduce glucose levels in diabetic rodent models and in primate models. The elegant use of liver-specific ...
22. Bungard, D. et al. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 329, 1201–1205 (2010). 23. Li, Y. et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and ...
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it has been hypothesized that there may be similar signaling proteins involved in the translocation process.Insulin signalinginvolves the rapid phosphorylation of theinsulin receptor, insulin receptor substrate-1/2 (IRS-1/2) ontyrosine residues, and the activation of phosphatidylinositol 3-kinase (PI3-...
Frigerio M, Cockcroft XF, Chong WY, Hummersone M, Rigoreau L, Menear KA, O'Connor MJ, Povirk LF, van Meter T, Valerie K (2009) Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion...
Dietary advanced glycation end-product restriction for the attenuation of insulin resistance, oxidative stress and endothelial dysfunction: a systematic review. Eur J Clin Nutr 2013;67:239–48.). Thus, it is an effective pharmacological approach to attenuate hyperglycemia-induced endothelial dysfunction ...
Inhibition of denosine monophosphate-activated protein kinase-3-hydroxy-3-methylglutaryl coenzyme A reductase signaling leads to hypercholesterolemia and promotes hepatic steatosis and insulin resistance Hepatol. Commun., 3 (1) (2019), pp. 84-98 CrossrefView in ScopusGoogle Scholar [95] M.D. Fuller...