Glucose metabolism and AMPK signaling regulate dopaminergic cell death induced by gene (alpha-Synuclein)- environment (Paraquat) interactions. Mol. Neurobiol [Epub ahead of print].Anandhan, A.; Lei, S.; Levytskyy, R.; Pappa, A.; Panayiotidis, M.I.; Cerny, R.L.; Kalimonchuk, O.; ...
J. et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310, 1642–1646 (2005). 65. Shackelford, D. B. & Shaw, R. J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat. Rev. Cancer 9, 563–575 (2009...
118. Hasenour, C. M. et al. 5-Aminoimidazole-4- carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo. J. Biol. Chem. 289, 5950–5959 (2014). 119. Puigserver...
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cytokines such as leptin ,adiponectin and ghre 2lin.The recent finding that anti 2diabetic drug metformin and TZ D regulates glucose metabolism through the activation of AMPK suggested a possible role of AMPK in protecting the body from metabolic diseases such as metabolic syndrome ,obesity and ...
AMPK对线粒体稳态的调节机制 图片来源:AMPK: guardian of metabolism and mitochondrial homeostasis【5】 就在不久前,《Journal of Investigative Dermatology》上发表的一项研究就直接指出:细胞外SOD通过 AMPK 和 Nrf2/HO-1 级联反应可以促进胶原蛋白生成,防止皮肤老化【8】。 图片来源:Extracellular superoxide ...
[16] Martin IK, Katz A andWahrenJ.Splanchnicand muscle metabolism during exercise in NIDDM patients[J]. Am JPhysiol, 1995, 269:E583-590. [17] Han X,PlougT andGalboH. Effect of diet on insulin- and contraction-mediated glucose transport and uptake in rat muscle[J]. Am JPhysiol, 1995...
不同于以往激活剂,“辟谷精”是合作团队耗时六年,综合抗衰领域最经典干预措施卡路里限制,以及林圣彩院士组近年发现的全新AMPK激活通路,独家开发的新型激活剂。该突破性成果发表于权威期刊Nature Metabolism。 作为代谢稳态的关键控制器,AMPK是一...