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diabetes cancerCells must coordinate diverse processes including cell division, cell migration, and cell polarity with the cells metabolic status. How single molecules coordinate these seemingly distinct cell biological events remains relatively unexplored. AMP-activated protein kinase (AMPK) sits at a ...
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Disruptions in the cycling of O-GlcNAc mediated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), respectively, is a driving force for aberrant cell signaling in disease pathologies, such as diabetes, obesity, Alzheimer's disease, and cancer. Production of UDP-GlcNAc, the metabolic ...
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Intact Regulation of the AMPK Signaling Network in Response to Exercise and Insulin in Skeletal Muscle of Male Patients With Type 2 Diabetes: Illumination ... 2016. Intact regulation of the AMPK signaling network in response to exercise and insulin in skeletal muscle of male patients with Type 2...
81. Cool, B. et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 3, 403–416 (2006). 82. Xiao, B. et al. Structural basis of AMPK regulation by small molecule activators. Nat...