Purpose: Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, is an antidiabetic drug. It has been shown to improve the Psoriasis Area and Severity Index (PASI) in patients with type 2 diabetes and psoriasis in clinical practice, but the mechanism remains somewhat unclear. We used ...
目的研究盐酸药根碱(JAT)对NCI-H716细胞分泌GLP-1的促进作用,并初步阐明JAT恢复内源性GLP-1分泌作用与AMPK/PKC信号通路相关。方法采用CCK-8法检测不同浓度JAT(6、30、60、90、150、300μmol/L)对NCI-H716细胞活性的影响,筛选150μmol/L JAT作为本实验基本浓度。分别选择JAT低、中、高浓度(100、150、200μ...
新西兰OXYENERGY氧气能量GLP+AMPK双效爆燃丸参考价: ￥299.00 声明:仅提供信息展示服务,产品信息来自互联网合法销售平台,如信息有误点我反馈 广告 没营销套路的厂家团购群 申请进群 > 产品信息 美国品牌:OXYENERGY/氧气能量 生产企业:Megadairy Limited 主要成分:藤黄果、非洲芒果、石榴皮等 产品含量:90粒 ...
AMPK 通过磷酸化乙酰辅酶 A 羧化酶 1 (ACC1) 和 ACC2,可以减缓已给予慢性二甲双胍治疗的糖尿病小鼠肝脂肪变性和动脉粥样硬化。十二指肠激活AMPK对于 L 细胞中 GLP-1 的分泌至关重要,同时也是口服二甲双胍发挥急性降糖作用的必要条件。此外,二甲双胍介导的C.秀丽隐杆线虫的老化延缓也是通过 AMPK 依赖性机制实现...
GLP-1 receptor agonists (GLP-1 RA) have been proven to treat several metabolic diseases; however, the effects of GLP-1 RA on polycystic ovary syndrome (PCOS) remain unclear. Here, we aimed to investigate whether semaglutide, a novel GLP-1 RA, could alleviate ovarian inflammation in PCOS mic...
摘要: 目的 观察白虎加人参汤对2型糖尿病(type 2 diabetes mellitus,T2DM)MKR小鼠肠道解偶联蛋白2(uncoupling pro-tein 2,UCP2)、AMP活化蛋白激酶(AMP-activated protein kinase,AMPK)表达及胰高血糖素样肽-1(glucagon like... 查看全部>> 暂无资源 收藏 引用 分享 推荐文章 肠道GLP-1受体表达水平与T2 ...
Fructo-oligosaccharides alleviate inflammation-associated apoptosis of GLP-1 secreting L cells via inhibition of iNOS and cleaved caspase-3 expression J. Pharmacol. Sci. (2020) Google Scholar [50] A.M. Armanian, A. Sadeghnia, M. Hoseinzadeh, M. Mirlohi, A. Feizi, N. Salehimehr, N. Sa...
GLP-1Rs and intracellular signaling pathways were identified by Western blot. The migration of macrophage was detecting by trans-well assay. Liraglutide decreased cell viability in the HaCat cells. Liraglutide restrained the migration of macrophage to the HaCat cells. LPS elevated not only the ...
The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism. J. Transl. Med. 14 (1), 229.Andreozzi F,Raciti GA,Nigro C,et al.The GLP-1 receptor agonists exenatide and liraglutide activate glucose transport by an AMPK-dependent mechanism[J]....