GLUT1FerroptosisGestational diabetes mellitusFetal growth restrictionAMPK/ACC pathwayGestational diabetes mellitus (GDM) has been associated with several fetal complications, such as macrosomia and fetal growth restriction (FGR). Infants from GDM associated FGR are at increased risk for adult-onset obesity...
Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen C-H, Wen J, Asara J, McGraw TE. 2013. AMPK- dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell 49: 1167-1175....
Hereby, I/Chenyan Lv/ consciously assure that for the manuscript / Chicoric acid encapsulated within ferritin inhibits tau phosphorylation by regulating AMPK and GluT1 signaling cascade/ the following is fulfilled: Declaration of Competing Interest The authors declare that they have no known competing ...
每周训练6天.9周后分别测定各组大鼠腓肠肌糖原,AMPK活性和肌膜GLUT4含量.结果:与A组比较,B组肌膜GLUT4升高,AMPK活性显著提高,肌糖原含量有上升趋势;C组肌膜GLUT4明显低于B组,AMPK活性受到抑制,但肌糖原含量正常.结论:过度训练状态下,大鼠肌肉AMPK活性降低,GLUT4蛋白向肌膜转位受抑,可能影响肌膜葡萄糖的转运.本...
Buller CL, Heilig CW, Brosius FC 3rd (2011) GLUT1 enhances mTOR activity independently of TSC2 and AMPK. Am J Physiol Renal Physiol 301:F588–F596Buller, C. L., C. W. Heilig, and F. C. Brosius III. 2011. GLUT1 enhances mTOR activity independently of TSC2 and AMPK. Am. J. ...
GLUT1 enhances mTOR activity independently of TSC2 and AMPK. Carolyn L. Buller,Charles W. Heilig,Frank C. Brosius. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY . 2011Buller CL, Heilig CW, Brosius FC 3rd: GLUT1 enhances mTOR activity independently of TSC2 and AMPK. Am J Physiol Renal ...
In addition, we show that energy stress results in the phosphorylation of TXNIP by AMP-dependent protein kinase (AMPK), leading to its rapid degradation. This suppression of TXNIP results in an acute increase in GLUT1 function and an increase in GLUT1 mRNA (hence the total protein levels) ...
虽然吸烟被认为是肺癌最主要和已确证的危险因素,但非吸烟患者数量逐年递增,因此除吸烟之外的致癌病因的探索是很有必要的.近年来,HPV与肺癌相关性逐渐的引起研究者重视起来.HPV16 E6/E7蛋白是主要的致癌基因.癌细胞利用Warburg效应消耗更多的葡萄糖,通过有氧糖酵解获得能量,活化的GLUT1是该过程中的主要葡萄糖转运蛋白...
采用了干扰技术来调控肺癌细胞中AMPK的表达,并通过Western blotting和Real-time PCR实验检测GLUT1蛋白和m RNA的表达水平.5.采用免疫荧光实验技术和葡萄糖摄取实验技术,通过共聚焦显微镜观察GLUT1的质膜分布情况与葡萄糖摄取情况.6.应用SPSS22.0统计分析软件,处理分析实验数据,以p<0.05表示具有显著性差异.结果:1.我们...
Roles of CA were proposed to regulate glucose metabolism by increasing GluT1 and promote glycosylation of tau protein. Meanwhile, CA was proved to inhibit phosphorylation of AMPK, which may further inhibit tau phosphorylation. These findings may provide a novel strategy to prevent neurodegenerative ...