AMPK Regulates ATGL-1 Association with Lipid Droplets in Dauer Larvae.Meng, XieRichard, Roy
The novel non-steroidal MR antagonist finerenone improves metabolic parameters in high-fat diet-fed mice and activates brown adipose tissue via AMPK-ATGL pathwayVincenzo Marzolla, Alessandra Feraco, Stefania Gorini, Caterina Mammi, Carmen Marrese, Valentina Mularoni, Carla Boitani, Marc ...
Phosphorylation sites have been identified in desnutrin, serine 406 and 430. We aimed to establish the regulatory activity of these residues in vitro and in vivo and to ask if AMPK is the kinase that phosphorylates these sites. Our data show that AMPK phosphorylates desnutrin at S406 but not...
過 貝特類藥物透過 PPAR α/AMPK/FoxO1/ATGL 路徑減少肌肉細胞中脂肪堆積情形路徑減少肌肉細胞中脂肪堆積情形 Fenofibrate lowers lipid accumulation in myotubes by modulating PPARα/AMPK/FoxO1/ATGL pathway
The role of Desnutrin/ATGL in promoting a brown‐adipose‐phenotype and regulation via AMPKDesnutrin/ATGL has been identified as the major triacylglycerol (TAG) lipase in adipose tissue and is induced during fasting. To further establish the role of desnutrin in adipocyte lipolysis we generated ...
ATGL 的啟動子上且調控 ATGL 的轉錄活性.在動物實驗中,以 fenofibrate 投予 db/db 小鼠,可降低小鼠體重與血清中三酸甘油脂含量,肝臟與肌肉內臟脂肪堆積減少,增加 AMPK ,ACC 磷酸化,也增加 ATGL 表現.根據以上結果,fenofibrate 降低脂肪是透過活化 PPAR-a和 AMPK 訊息路徑,來增加 ATGL 表現量並促進脂肪分解及...
AMPK-Mediated Phosphorylation of ATGL-1 Enhances Ubiquitin-Mediated Degradation via the Proteasome.Meng XieRichard Roy
S. (2011) Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab. 13, 739-748Ahmadian M, Abbott MJ, Tang T, et al. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab 2011;13:739-48....
Thus, camptothecin activation of SIRT1 promotes lipid catabolism through AMPK/FoxO1/ATGL signaling.doi:10.1007/s12272-019-01155-8Lo, Mei-ChenChen, Jia-YinKuo, Yung-TingChen, Wei-LuLee, Horng-MoWang, Shyang-GuangSpringerArchives of Pharmacal Research...
Duncan,Chulho Kang,Hei Sook Sul.Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype[J]. Cell Metabolism .2011(6)Ahmadian M, Abbott MJ, Tang T, et al. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab 2011;13:...