Liangshuo,Hu,Lin,etc.AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model.[J].2019,97(3).Hu, Liangshuo,Su,etc.AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in theBDL rat model[J].2019,97(3)....
Renal tubulointerstitial fibrosis was a crucial pathological feature of diabetic nephropathy (DN), and renal tubular injury might associate with abnormal mitophagy. In this study, we investigated the effects and molecular mechanisms of AMPK agonist metfo
AMPK AGONIST AND INHIBITOR KIT CAS号: 英文名: AMPK agonist and inhibitor kit 英文别名: AMPK agonist and inhibitor kit 中文名: AMPK AGONIST AND INHIBITOR KIT 中文别名: CBNumber: CB75707187 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 ...
摘要 Macrophages rapidly undergo glycolytic reprogramming in response to macroautophagy/autophagy, inflammasome activation and pyroptosis for the clearance of bacteria. Identification the key molecules involved in these three events will provide critical potential therapeutic applications. Upon S. typhimurium inf...
In the mouse carbon tetrachloride (CCl4) model, treatment with the AMPK agonist 5-Aminoimidazole-4-carboxamide1-β-D-ribofuranoside (AICAR) suppressed HSC proliferation and collagen-α1 expression and correlated with attenuated hepatic fibrosis and improved liver function [41]. These studies indicate ...
METHODS Totally 36 rats were randomly divided into blank group,model group,XBN group(12.56 g/kg), XBN+metformin(AMPK agonist)group(12.56 g/kg XBN+100 mg/kg metformin),with 9 rats in each group. Except for blank group,KOA model was induced by anterior cruciate ligament transection in other...
AMPK direct agonist A769662 and indirect agonist Metformin were given for 12 weeks to investigate the expressions of inflammatory factors related to macrophages in adipose tissue. Oral glucose tolerance test (OGTT) was performed by mouse tail tip ...
The AMPK-agonist AICAR, and activated AMPK adenovirus, inhibited mTOR signaling and blocked the growth of glioblastoma cells expressing the activated EGFR mutant, EGFRvIII. Across a spectrum of EGFR-activated cancer cell lines, AICAR was more effective than rapamycin at blocking tumor cell ...
Description Similar Products Reviews Product Description AICAR is a natural metabolic intermediate of the purine biosynthetic pathway. In its monophosphate form, AICAR is a potent AMPK agonist, which at low concentrations, does not affect AMP, ADP, or ATP levels. [1] AICAR's interacts directly wit...
AICAR is a commonly used AMPK agonist, it can be absorbed and metabolized by tissues in the body into ZMP, an analog of AMP, thereby activating AMPK and promoting glucose uptake by tissues50. Studies have found that AICAR stimulation in rats can increase AMPK activity, thereby improving ...