metforminhyaluronan and proteoglycan link protein 1therapeutic targetAMP-activated protein kinase (AMPK) is essential for maintaining energy balance and has a crucial role in various inflammatory pathways. In this study, AMPK levels positively correlated with many inflammatory indexes in rheumatoid arthritis...
Recently, various studies demonstrate that the increased activity of adenosine 5′-monophosphate-activated protein kinase (AMPK) causes health benefits in energy regulation. Thus, great efforts have been made to develop AMPK activators as a metabolic syndrome treatment. In the present study, we ...
Because mitochondrial membrane potential controls calcium homeostasis, and AMP-activated protein kinase (AMPK) is regulated, in part, by intracellular calcium, we postulated that AMPK participates in STING activation; however, its role has yet to be been defined. Addition of an intracellular calcium ...
The evolutionarily conserved AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis that controls multiple branches of metabolism to redress energy imbalances caused by physiological and pathological processes1,2. AMPK senses increased cellular AMP/ATP ratio ...
5′-腺苷单磷酸(5′-adenosine monophosphate, AMP)激活的蛋白激酶(AMP-activated protein kinase, Ampk)是代谢信号通路的中枢调节因子,可感知胞内能量供给的波动,以敏锐地调控分解与合成代谢的平衡。有证据表明,在饥饿、缺氧、线粒体功能受损和疾病状态(如...
5’-单磷酸腺苷活化蛋白激酶(5′-adenosine monophosphate-activated protein kinase, AMPK)是细胞内几乎是最重要的能量感受器,可以感知细胞内AMP/ATP和(或)ADP/ATP比例变化而被激活,在调节细胞生长、增殖、维持机体能量平衡以及细胞代谢过...
5’-单磷酸腺苷活化蛋白激酶(5′-adenosine monophosphate-activated protein kinase, AMPK)是细胞内几乎是最重要的能量感受器,可以感知细胞内AMP/ATP和(或)ADP/ATP比例变化而被激活,在调节细胞生长、增殖、维持机体能量平衡以及细胞代谢过程中起着重要作用。 之前普遍认为AMPK的激活依赖于细胞内AMP浓度的变化。2019年,...
AICAR是一种可通透细胞膜AMP-activated protein kinase(AMPK)的激活剂。AMPK是代谢调控的关键蛋白,当能量供应不足时,AMP/ATP的比率上调,AMPK就会被激活,抑制合成代谢。AICAR可以激活AMPK,但不影响ATP、ADP和AMP的水平。在细胞或动物水平,AICAR可以通过激活AMPK从而促进骨骼肌非胰岛素依赖的葡萄糖摄入。AICAR诱导的骨骼肌...
5’-单磷酸腺苷活化蛋白激酶(5′-adenosine monophosphate-activated protein kinase, AMPK)是细胞内几乎是最重要的能量感受器,可以感知细胞内AMP/ATP和(或)ADP/ATP比例变化而被激活,在调节细胞生长、增殖、维持机体能量平衡以及细胞代谢过程中起着重要作用。 ...
a natural polyphenolic compound found in plants like chicory and basil, has garnered attention for its anti-inflammatory and antidiabetic properties. The researchers investigated its potential to regulate glucose uptake and insulin sensitivity, focusing on the AMP-activated protein kinase (AMPK) pathway...