AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in theBDL rat modelPortal hypertension, Liver cirrhosis, AMP-activated protein kinase, AICAR, Nitric oxideRecent studies have indicated that the Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway...
由于作者观察到 AMPK 激动剂可以逆转 flt4 ΔLBD/ΔLBD 巨噬细胞在调节自噬和炎症小体激活方面的表型,作者继续思考FLT4 是否通过下游 AMPK 调节葡萄糖代谢。为了回答这个问题,作者使用激动剂 AICAR 在 Flt4 WT/WT 和 flt4 ΔLBD/ΔLBD 巨噬细胞中激活 AMPK(图 5H)。在静息状态下,Flt4 WT/WT 和 flt4...
1.Daignan-Fornier et al., 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects Metabolites 2012, 2, 292-302. Pubmed ID:ISSN: 2218-1989 2.Guo et al., The AMPK agonist AICAR inhibits the growth of EGFRv...
The AMPK-agonist AICAR, and activated AMPK adenovirus, inhibited mTOR signaling and blocked the growth of glioblastoma cells expressing the activated EGFR mutant, EGFRvIII. Across a spectrum of EGFR-activated cancer cell lines, AICAR was more effective than rapamycin at blocking tumor cell ...
Our preliminary investigations into the role of the LKB1-AMPK signalling pathway appeared entirely consistent with this view, in that pharmacological studies suggested that the AMPK agonist AICAR (Corton et al., 1995) activated carotid body type I cells and increased afferent discharge from isolated ...
Some studies showed that systemic administration of the AMPK agonist AICAR increased spatial memory and improved motor function in young and old female mice (Kobilo et al, 2014; Kobilo et al, 2011). Other studies found that the activation of AMPK impaired long-term spatial memory (Dash et ...
Consistent with these results, when the AMPK agonist AICAR was added in combination with BMP2, mineralization evaluated by Alizarin Red staining (Fig. 3E) and quantification (Fig. 3F) was greater in LV-AMPKα2 than in LV-AMPKα1 cells on days 9 and 12. Primary osteoblasts ...
In the mouse carbon tetrachloride (CCl4) model, treatment with the AMPK agonist 5-Aminoimidazole-4-carboxamide1-β-D-ribofuranoside (AICAR) suppressed HSC proliferation and collagen-α1 expression and correlated with attenuated hepatic fibrosis and improved liver function [41]. These studies indicate ...
It has been demonstrated that despite different compounds activating the same target, the effect maybe varies because of the nature and timing of the activation57. In our study, the AMP-mimic AICAR, was able to prevent skin ulcer slightly, but was not as good as cordycepin, while metformin ...
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis Radu, T.F. Cloughesy, P.S. Mischel, The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis, Proc. ... D.,Guo,I.,... - 《Proceedings of...