At the molecular level, this aberration rearranges the gene for the AML1-transcription factor on chromosome 21, which is essential for normal hematopoiesis, to the MTG8 gene on chromosome 8, thereby leading to a specific AML1/MTG8 fusion mRNA. This fusion gene is involved in leukemogenesis ...
近50%的急性髓系白血病可以找到染色体易位,常见的染色体易位是t(8;21)(q22;q22).这种易位使21号染色体上的aml1(runx1)基因与8号染色体上的eto(mtg8,runx1t1)基因相互... 曾慧敏,郭晔,竺晓凡 - 《中国实验血液学杂志》 被引量: 7发表: 2010年 急性髓系白血病M2b型患者AML1与MTG8基因重排融合的研究 作者研...
The translocation t(8;21) yields the leukemic fusion gene AML1/MTG8 and is associated with 10%-15% of all de novo cases of acute myeloid leukemia. We demonstrate the efficient and specific suppression of AML1/MTG8 by small interfering RNAs (siRNAs) in the human leukemic cell lines Kasumi...
慢性粒细胞白血病的特征遗传学标志是 A.PML-RARα融合基因B.DEK-CAN融合基因C.AML1-MTG8融合基因D.Ph染色体E.E
摘要: International Journal of Hematology - The chimeric oncogene AML1-MTG8 (RUNX1-RUNX1T1) is generated in t(8;21) acute myeloid leukemia (AML). Here, we report a novel interaction of MTG8/RUNX1T1/ETO...关键词:AML1 RUNX1 MTG8 ETO UBC9 ...
Because PCR detected the AML1/MTG8(ETO) fusion with high sensitivity, it can be used for the diagnosis and detection of minimal residual disease in t(8;21) AML. MATERIALS AND METHODS cDNA cloning. The cDNA cloning strategy was that of Frohmen et al,12 with the following modification. ...
Early detection of AML1/MTG8 fusion mRNA by RT-PCR in the bone marrow cells from a patient with isolated granulocytic sarcoma. Leukemia 1998;12:1501-3.T. Hayashi, M. Kimura, S. Satoh et al., "Early detection of AML1/MTG8 fusion mRNA by RT-PCR in the bone mar- row cells from a...
The AML1-MTG8 Leukemic Fusion Protein Forms a Complex with a Novel Member of the MTG8(ETO/CDR) Family, MTGR1 The AML1-CBFbeta transcription factor complex is essential for the definitive hematopoiesis of all lineages and is the most frequent target of chromosomal ... I Kitabayashi,K Ida,...
机译:WT1基因表达在检测微小残留病变中的意义-AML1-MTG8嵌合基因与WT1基因表达的比较- 2. 原著論文編論文要旨 水環境におけるふん便指標細菌である大腸菌は,環境中で再増殖することが知られており,指標細菌としての妥当性が 懸念されている。そこで本研究では,下水処理水が流入する小河川において,下...
In conclusion, siRNA-mediated suppression ofcause very similar changes in gene expression pattern in t(8;21)-positive cell lines and in primary AML blasts. Furthermore, the results suggest that the specific targeting of AML1/MTG8 function may be a promising approach for complementing existing ...