AML1-MTG16融合基因白血病致瘤性目的 研究用重叠延伸剪接术 (splicing overlaping extension,SOE)方法获取少见融合基因的转录本。了解 AML1- MTG16融合基因的致瘤性。方法 通过 SOE重组 ,将 AML1、MTG16基因的两个片段经 PCR融合起来 ,形成 AML 1- MTG16融合基因的编码部分。将 MTG16 ,AML 1- MTG16融合基因...
AML1-MTG16 protein Basic informationMore.. Product Name:AML1-MTG16 protein Synonyms:AML1-MTG16 protein CAS: MF: MW:0 EINECS: Mol File:Mol File Information Error Report Your Email: Browse by provinceAML1-MTG16 proteinSuppliersGlobal suppliers ...
AML1- MTG16质粒稳定转染的 NIH3T3细胞的生长曲线 ,后者增殖明显.软琼脂克隆形成试验显示 ,转染了 p EGFP- C1的 NIH3T3细胞在 6孔板内未形成克隆 ;转染了 p EGFP- C1-AML1- MTG16的 NIH3T3细胞在 6孔板内每孔平均形成 (47.7± 2 .7)个克隆 ,且使裸鼠致瘤.通过激光共聚焦显微镜观察 ,融合有 MTG16,...
t(1621)(q24q22)A chimeric gene, AML1-MTG16, showing high homology to AML1-MTG8, was recently identified in adult leukemic patients with the abnormal karyotype t(16;21)(q24;q22). We recently saw a child patient of 11 years of age who developed acute myelogenous leukemia with the ...
Kondoh, K, Nakata, Y, Furuta, T, Hosoda, F, Gamou, T, Kurosawa, Y (2002) A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene. Leuk Lymphoma 43: pp. 415-420Kondoh K, Nakata Y, Furuta T, Hosoda F, Gamou T, Kurosawa...
Myeloid maturation block by AML1-MTG16 is associated with Csf1r epigenetic down- regulation. Oncogene 24, 5325-5332.Rossetti S, Van Unen L, Touw IP, et al: Myeloid maturation block by AML1‑MTG16 is associated with Csf1r epigenetic downregu- lation. Oncogene 24: 5325‑5332, 2005....