MDSAML with MRCdetectable gene mutationsA subset of AML with myelodysplastic syndrome (MDS)-related changes (MRCs) occurs without a documented MDS phase. We studied genomic profile of 646 patients: 310 with MDS, 167 with AML without (w/o) MRC, 99 with primary (p) AML-MRC, and 70 with ...
【翻译】在前期为MDS的患者中,常仅有部分原始细胞表达CD34,可有干细胞相关免疫表型,即低表达CD38和/或HLA-DR。 An increase in the fraction of cells with this stem-cell immunophenotype has been correlated with high―risk cytogenetics a...
急性髓系白血病伴骨髓增生异常相关改变(acute myeloid leu-kaemia with myelodysplasia-related changes, AML-MRC)是AML的一种独特的亚型,占AML的25-34%,其预后较差[1],是一种具有多系发育异常,或具有MDS或MDS/MPN病史,或具MDS相关细胞遗传学异常的AML...
②当外周血/骨髓原始细胞≥20％时，若存在CEBPA双等位基因突变，则即使有多系病态造血的形态学特征也不再分类为AML-MRC，而应诊断为AML伴CEBPA双等位基因突变。③当外周血/骨髓原始细胞≥20％时，若有MDS病史或者骨髓增生异常相关细胞遗传学改变[ 如del(11q) ]，即使有CEBPA双等位基因突变，仍应诊断为AML-MRC。...
目的比较非血缘脐血干细胞移植(UCBT)与同胞HLA全相合供者造血干细胞移植(MSD-HSCT)治疗骨髓增生异常综合征伴原始细胞增多(MDS-EB)和急性髓系白血病伴骨髓增生异常相关改变(AML-MRC)的临床疗效。 方法回顾性分析2011年2月至2017年12月接受UCBT/MSD-HSCT的MDS-EB/AML-MRC患者64例,其中MDS-EB 38例,AML-MRC 26例...
We, herein, characterized the changes in cytokine expression and the function of mesenchymal stromal cells (MSC) in patients with MDS, AML with myelodysplasia-related changes (MRC), a well-recognized clinical subtype of secondary AML, andAML. We observed a significant inhibitory effect of MDS-...
A subset of AML with myelodysplastic syndrome (MDS)-related changes (MRCs) occurs without a documented MDS phase. We studied genomic profile of 646 patients: 310 with MDS, 167 with AML without (w/o) MRC, 99 with primary (p) AML-MRC, and 70 with secondary (s) AML-MRC and sought to...
A case report of AML with myelodysplasia-related changes with aggressive course in association with t(3;8)(q26;q24)t(38)(q26q24)MDSAMLTransformationMyelodysplastic syndrome (MDS) is frequently associated with clonal cytogenetic abnormalities which are major predictors of the disease outcome. t(3...
as chronic myelomonocytic leukemia (CMML); an MDS related cytogenetic abnormality; or multilineage dysplasia in 50% or more of two or more cell lines in the absence of NPM1 or biallelic CEBPA mutations [1]. The classifcation of AML-MRC overlaps somewhat with the traditional term ...
scRNA-seq and epigenetic-related chemoresistance The molecular mechanisms involved in response to decitabine in AML and myelodysplastic syndrome (MDS) are still not fully understood. The aim of this study investigating these mechanism using scRNA-seq. Total BM aspirate cells from 10 patients were colle...