MDS和MM中TP53突变的频率分别为7%-19%和8%-15%,TP53突变克隆可能驱动疾病进展。在MDS中,p53核表达与半合子TP53突变相关(一个等位基因的丢失、另一个突变),并且>1%的骨髓祖细胞中的强p53免疫染色与AML的高风险相关。在MM中,TP53突变...
Results Twenty-six patients with de novo AML (n=19), secondary AML transformed from MDS (n=4), or MDS-EB2 (n=3) were enrolled with a median age of 48 years (range, 23~65 years). Patient and disease characteristics are summarized in Table 1. Nineteen patients had adverse risk ...
Although the majority present de novo, AML can be secondary to conditions such as myelodysplastic syndrome (MDS) and myeloproliferative neoplasms (MPNs) including polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF). The subset of patients with AML transformed from MPN ...
We investigated 350 patients—283 s-AML after MDS and 67 transformed MPNs—formut.mut was detected in 43/350 patients (12.3%) at diagnosis of s-AML (transformed MDS: 37/283; 13.1%; transformed MPNs: 6/67; 9.0%). Cytogenetic alterations were present in 12/40 cases (30.0%) with ...
The expression of CD 133 were highly positive in 2AMLpatients transformed from MDS. 2例MDS转化 的AML均为CD133高表达. 互联网 Objective To explore the immunophenotype of children with acute myeloid leukemia (AML) and its clinical significance. ...
The expression of CD 133 were highly positive in 2AMLpatients transformed from MDS. 2例MDS转化 的AML均为CD133高表达. 互联网 Objective To explore the immunophenotype of children with acute myeloid leukemia (AML) and its clinical significance. ...
Theocharides A, Boissinot M, Girodon F et al (2007) Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation. Blood 110:375–379 ArticleCASPubMedGoogle Scholar Thirman MJ, Gill HJ, Burnett RC et al (1993) Rearrangemen...
Data were transformed to log2 scale. Then, we imputed missing values and replaced them from a normal distribution. The protein quantification and calculation of statistical significance were performed with a two-sample t-test and with a permutation-based correction controlled with an FDR threshold ...
In all these 5 transformed MPN cases the initial typical MPN mutation was retained in AML (blast crisis) whereas the NPM1 mutation was acquired and may have served as a second hit in the development to AML. One of the two JAK2+/NPM1+ cases in addition also acquired an FLT3-ITD. From...
Transformed gene expression data were analyzed with Partek Genomics Suite Version 6.4 (Partek Inc). Microarray data can be downloaded at Gene Expression Omnibus (National Center for Biotechnology Information) under accession number GSE21261.35 Statistical analysis Mean differences were analyzed with the ...