9. Lyu M, Liao H, Shuai X et al. The prognosis predictive value of FMS-like tyrosine kinase 3-internal tandem duplications mutant allelic ratio (FLT3-ITD MR) in patients with acute myeloid leukemia detected by GeneScan...
Key Conferences Shape the Future of Cell and Gene Therapy Recommendations and Future Directions of Genetic Testing for CLL Advancing Trials for HER2+ Breast Cancer With Leptomeningeal Metastasis A Deeper Dive Into Polygenic Risk Scoring for CLL Insights on Tucatinib Regimens in HER2+ Breast Cancer Trea...
Activating mutations of the FLT3 gene occur because of an internal tandem duplication of the juxta-membrane domain (FLT3/ITD) or point mutation of the acti... S Meshinchi,TA Alonzo,DL Stirewalt,... - 《Blood》 被引量: 506发表: 2006年 In vitro analyses of known and novel RUNX1/AML1 ...
9. Lyu M, Liao H, Shuai X et al. The prognosis predictive value of FMS-like tyrosine kinase 3-internal tandem duplications mutant allelic ratio (FLT3-ITD MR) in patients with acute myeloid leukemia detected by GeneScan. Gene 2020;726:144195. 10. Liu S-B, Dong H-J, Bao X-B et al...
21. Au CH, Wa A, Ho DN et al. Clinical evaluation of panel testing by next-generation sequencing (NGS) for gene mutations in myeloid neoplasms. Diagn Pathol 2016;11:11. 23. Wang T-Y, Yang R. ScanITD: Detecting internal tandem duplication with robust variant allele frequency estimation. ...
Conclusions Panel testing for gene mutations is effective method for detection of AML molecular markers. For the patients came with partial remission and without gene mutation result, archived bone marrow smear sample can be used for retrospective mutation analysis and then help guiding targeted therapy...
Molecular genetic testing should be used to screen for genetic abnormalities that define disease or risk categories, or those that are needed for targeted treatments. A dedicated gene panel for known predisposing alleles should be used when AML with germline predisposition is suspected. In NPM1-mutat...
21. Au CH, Wa A, Ho DN et al. Clinical evaluation of panel testing by next-generation sequencing (NGS) for gene mutations in myeloid neoplasms. Diagn Pathol 2016;11:11. 22. Blätte TJ, Schmalbrock LK, Skambraks S et al. getITD for FLT3-ITD-based MRD monitoring in AML. Leukemia ...
基于高通量测序技术的105例AML和MDS患者驱动基因突变谱差异性分析 专家简介:陈雪萍,女,临床检验诊断学博士,重庆医科大学附属第一医院临床分子医学检测中心主管技师,在职博士后㊂主要研究方向为高通量测序相关实体肿瘤伴随诊断㊁肿瘤遗传易感性㊁血液肿瘤分子分型㊁遗传病等相关基因检测㊂参与发表S C I 论文10余篇...
Even within individual patients, somatic mutation changes can vary depending on the specific clone producing each cell37,38,39. This diversity is well-established and is associated with various prognoses based on coexisting gene mutations, particularly among AML patients with mutated NPM14,40. While ...