Gale, S.J. Rollinson, et al., Mutation of the AML 1 gene in acute myeloid leukemia of FAB types M0 and M7, Genes Chromosomes Cancer 34 (2002) 24-32.Langabeer SE, Gale RE, Rollinson SJ, Morgan GJ, Linch DC. Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 ...
Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. 基因名: RUNX1 别名: AML1,AML1-EVI-1,AMLCR1,CBF2alpha,CBFA2,EVI-1,PEBP2aB,PEBP2alpha ...
and gene expression patterns offer valuable insights for AML patient outcomes (Lu et al.2022). Recent scRNA-seq studies on AML have revealed a variety of cells types, including primitive cells and differentiated cells, which may be linked to certain genomic features (Ediriwickrema et al.2023)....
we used the scRNA-seq data to derive gene signatures for each of the six malignant cell types,设计这些特征以平均权衡每种恶性细胞类型,并排除在AML细胞中普遍存在的正常细胞类型中表达的基因,从而将我们的方法与以前的研究(通过可变基因或分类人群的特征将AML分层)区别开来。We used our signatures to score ...
NPM1 mutations appear to precede FLT3―ITD. AML with mutated NPM1 shows a distinct gene expression profile (characterized by upregulation of HOX genes) that differs from that of other AML types, including AML with KMT2A rearrangement. AML wit...
[33]. TheTP53gene mutations of missense, nonsense, frameshift or in/dels types, may result in loss-of-function, gain-of-function or in the dominant negative effect [34] propensities of the mutated protein (reviewed in [35]). Yet, our understanding of the biology behind the multiple ...
Results Therewere statistically significant differences in WBC,RBC,HGB of peripheral blood and the mutation of DNMT3Agene(statistical values:705.000;-2.535;-2.290 and 5.715 respectively,all P < 0.05)in 2 types of AML.Conclusion When compared with FLT3⁃ITDwt de novo primary AML patients,FLT3...
and gene expression patterns offer valuable insights for AML patient outcomes (Lu et al.2022). Recent scRNA-seq studies on AML have revealed a variety of cells types, including primitive cells and differentiated cells, which may be linked to certain genomic features (Ediriwickrema et al.2023)...
Mutant-to-wild-type allelic ratio, insertion site, ITD length, karyotype, and the presence of a mutation in theNPM1gene appear to further influence the prognostic utility ofFLT3-ITD in patients with newly diagnosedFLT3-ITD-mutated AML. Higher allelic burden with theFLT3-ITD mutation has been ...
MigR1, MigR1-AML1-ETO (AE), and its amino acid mutation plasmids were described in Wang et al.23. TAF1 cDNA was purchased from Addgene; the full-length sequence was corrected and verified by DNA sequencing and reconstructed into the pCDH-MSCV-EF1 vector, purchased from SBI Biotech. The...