Furthermore, the 2.1 脜 crystal structure of [E271Q]leukotriene A 4 hydrolase revealed minimal conformational changes that could not explain the loss of enzyme function. We propose that the carboxylate of Glu-271 participates in an acid-induced opening of the epoxide moiety of leukotriene A 4 ...
The enzyme also serves as a receptor for coronaviruses and other human viruses, and influences immune function, cell proliferation, secretion, and angiogenesis (Luan and Xu 2007). APN, like GGT, is found in microvillus membranes in many tissues, but especially in renal proximal tubules, small ...
coli are affected by pH variation. PepN homologs are widespread in prokaryotes and eukaryotes and may function as the LBS hydrolase in var- ious strains. Two closely located PepN homologs from Streptomyces lividans were identified through blast search; PepN1 is 27% identical (114/427) and ...
Their possible physiological function is discussed. Functionally and structurally related enzymes are compared to the β-peptidyl aminopeptidases.doi:10.1007/s00253-007-0872-5B. GeuekeH. KohlerSpringer Berlin HeidelbergApplied Microbiology and Biotechnology...
Indirect evidence suggests that removal of initiator Met by MetAP is important for the normal function of many proteins involved in DNA repair, signal transduction, cell transformation, secretory vesicle trafficking, and viral capsid assembly and infection. Currently, much effort is focused on ...
Based on our results, we hypothesize that CAD, APN4 and ALP2 may function as receptors for the Cry2Aa toxin in H. armigera and play important functional roles in the mechanism of action of the Cry2Aa toxin. Results Toxicity of Cry1Ac and Cry2Aa to the susceptible H. armigera strain ...
segment missing in the former. This portion of MetAP 2 may also function to form a complex with other entities involved inprotein translation, including the ribosome, as suggested for eukaryotic MetAP 1. The type 2 enzymes from archaebacteria and eukaryotes are designated type 2a and b, resp...
Define aminopeptidase. aminopeptidase synonyms, aminopeptidase pronunciation, aminopeptidase translation, English dictionary definition of aminopeptidase. n. Any of various enzymes that catalyze the hydrolysis of the terminal peptide bond of a polypeptid
lymphocyte function-associated antigen 3 precursor, interstitial collagenase precursor, neutrophil collagenase precursor, motilin precursor, neuropilin-1 precursor, platelet-activating factor acetylhydrolase precursor, bone sialoprotein ii precursor, growth hormone variant precursor (Seeburg, DNA 1: 239-249 (19...
wherein hybridization between the marker nucleic acid molecule and the nucleic acid molecule derived from or within the cell permits the detection of a polymorphism whose presence is predictive of a mutation affecting the level or pattern of the MetAP-3 protein in the cell; (B) permitting hybrid...