cancer cells can form a huge mass (as in solid tumors) and also migrate to other parts of the body through either blood or lymphatic circulation [1]. In hematologic malignancies, cancer cells will eventually outnumber the normal blood
Three quercetin derivatives with enhanced radical-scavenging activity were designed and synthesised. Because the radical-scavenging reaction of quercetin is known to proceed via an electron transfer from quercetin to radicals, producing the corresponding quercetin radical cation intermediate, the introduction ...
The near century of progress1in cancer metabolism continues to impact our understanding of oncology. Each decade has yielded new discoveries and engendered additional avenues of research and approaches to therapy. Classically, cancer metabolism has focused on central carbon metabolism, including glycolysis ...
1A3, which gives tumor cells a survival advantage.92In another study on tumor metabolism, Sullivan et al. found that Asp synthesis was a limiting factor for bladder cancer growth when oxygen was lacking in the environment. In bladder cancer cells, the poor permeability of Asp cells prevents th...
Colorectal cancer is a serious complication of inflammatory bowel disease. Given this fact, it is necessary to examine the opportunities for current and fu... P Munkholm,Loftus Jr., Edward V.,A Reinacher-Schick,... - 《Digestion》 被引量: 228发表: 2006年 5-Aminosalicylate therapy is assoc...
YulinZou, ...TaoYu, inMolecular Therapy - Nucleic Acids, 2021 Aminoacylation The classic function of ARS is to precisely attach each type of amino acid to a specific tRNA in a process known asaminoacylation. Recently, significant studies have found that both cytoplasmic ARS and mitochondrial ARS...
Cell cancer GABA has become a crucial component in the domain of oncology, garnering considerable interest in recent scientific investigations due to its complex mechanistic functions in cancer therapy. The fundamental mechanism by which GABA impacts cancer therapeutics is through its interaction with a...
Adenovirus-mediated Transfer of Inducible Caspases A Novel "Death Switch" Gene Therapeutic Approach to Prostate Cancer In patients with localized , radical prostatectomy and radiation therapy, although effective in controlling , are often associated with significant side effects attributable to injury of ad...
Thus, targeting the considerable metabolic differences between cancer cells and normal cells holds promise as an ideal strategy for cancer therapy8. Many studies have reported that abnormal levels of lipids are critical for the unlimited proliferation and the metastasis and invasion of cancer cells9. ...
the design of new drugs with fewer side effects to inhibit polη in cancerous cells has attracted attention in recent years. This project aims to design and explore the alternative inhibitors for polη, which are based on carbohydrates and amino acids. In terms of physicochemical properties, the...