Solution: cysteine depletion, including a cancer patient, which determines the cystine thionine lyase lyase in the tissue and / or in the body fluid and determines the patient who is effective in cysteine depletion therapy A method of screening cancer patients who are effective in therapy.A drug...
- 《European Journal of Cancer & Clinical Oncology》 被引量: 183发表: 1983年 Influence of estrogen receptor status on response of metastatic breast cancer to aminoglutethimide therapy Aminoglutethimide (AG) is an effective chemical ablative form of therapy for metastatic breast cancer in ...
Our data suggest that the expression level of these amino-acid transporters has a crucial role in the development and carcinogenesis of tumour cells, and it may be an important clinical marker of therapy for patients with tongue cancer. L-type amino-acid transporter 1 is highly expressed in ...
AO-90 is a methionine-free amino acid solution based on the Vuj-N formulation and is intended for use in cancer therapy. The solution was administered via ... Y Hibino,Y Kawarabayashi,G Ebisu,... 被引量: 3发表: 1994年 Clinical Studies of Methionine-Restricted Diets for Cancer Patients:...
arginine depletion has lower toxicity profile and can effectively reduce the level of pro-cancer biochemicals in patients as shown by ours and others’ data. This supports the clinical use of arginine depletion as anti-cancer therapy but its exact efficacy in various cancers requires further investig...
microenvironment (TME). PDAC uses BCKAs secreted by CAFs as substrates for BCAAs synthesis or increases the oxidative metabolic flux of BCKA in a BCKDH-dependent mode.57This study suggests the feasibility of targeting BCAAs metabolism in TME mesenchymal and cancer cells for PDAC therapy (Fig.4...
In 1976, cys was first used for the treatment ofcystinosis, approved by the US Food and Drug Administration (FDA), and commercialized in the 1990s [6]. Till now, cys is the only specific targeted therapy available for patients with cystinosis. The latter is a rare autosomal recessivemetab...
Patients with moderate-to-severe psoriasis who were recruited for the study had a Psoriasis Area and Severity Index of 8.0 or greater and washout periods of at least 14 days for topical corticosteroids and any systemic therapy. Skin punch biopsy specimens (3 mm) were obtained from patients with...
Present address: Georg Speyer Haus Institute for Tumour Biology and Experimental Therapy, Paul-Ehrlich-Straße, Frankfurt, Germany David M. Gay Present address: Københavns Universitet, BRIC, Copenhagen, Denmark Rene Jackstadt Present address: Heidelberg Institute for Stem Cell Technology and Exper...
STARD3: A prospective target for cancer therapy. Cancers 13, 4693 (2021). Derré, I., Swiss, R. & Agaisse, H. The Lipid Transfer Protein CERT Interacts with the Chlamydia Inclusion Protein IncD and Participates to ER-Chlamydia inclusion membrane contact sites. PLOS Pathog. 7, e1002092 (...