Here we studied the organization of the amino terminal domain (ATD) of the rat GluN1/GluN2A and GluN1/GluN2B NMDA receptors by cysteine-directed, disulfide bond-mediated cross-linking. We found that GluN1 ATDs and GluN2 ATDs spontaneously formed disulfide bond-mediated dimers after ...
Amino acid residues critical for RNA-binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronav... The N-terminal domain of the coronavirus nucleocapsid (N) protein adopts a fold resembling a right hand with a flexible, positively charged...
amino terminal domain and carboxyl terminal domain. 氨基末端结构域和羧基末端结构域。 www.juyy.net 2. The carboxylate groups of hyaluronan were activated in order to bind the amino terminal groups of the di-amine cross-linking reagent. 的羧基透明质酸被激活,以约束氨基端组的双胺交联试剂。 www....
In this study, using CRISPR/Cas9 to delete the endogenous AMPARs and replace them with the mutant forms in single neurons, we have found that the amino-terminal domain (ATD) of GluA1 is required for LTP maintenance. Moreover, we show that GluA1 ATD directly interacts with the cell ...
amino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro downloaded from M Yoon,DH Smith,P Ward,... 被引量: 0发表: 0年 The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of...
We have studied an amino-terminal domain of hsp90 whose crystal structure has recently been solved and determined to contain a geldanamycin-binding site. We demonstrate that, in solution, drug binding is exclusive to this domain. This domain also binds ATP linked to Sepharose through the γ-...
monoclonal antibody cl5 recognizes the amino terminal domain of human phagocyte flavocytochrome b 558 large subunit, gp91 phox european journal of haematology Human phagocyte flavocytochrome b558 (Cyt b), the catalytic center of NADPH oxidase, consists of a heavily glycosylated large subunit (gp91pho...
Ionotropic glutamate receptors (iGluRs) mediate the majority of fast excitatory synaptic neurotransmission in the central nervous system. The selective assembly of iGluRs into AMPA, kainate, and N-methyl-d-aspartic acid (NMDA) receptor subtypes is regulated by their extracellular amino-terminal domains...
The tertiary structure of lipid-free apolipoprotein (apo) A-I in the monomeric state comprises two domains: a N-terminal α-helix bundle and a less organized C-terminal domain. This study examined how the N- and C-terminal segments o... M Tanaka,P Dhanasekaran,D Nguyen,... - 《...
These proteins have a molecular mass of 15–19 kDa and share multiple structural motifs, including an actin-depolymerizing factor homology (ADF-H) domain that allows for binding to actin, a central alpha-helix, an N-terminal extension, and a C-terminal helix2,3. Cofilins exert their ...