6) carboxy-terminal domain (CTD) C末端结构域 1. Many experiments showed that mRNA transcriptional termina-tion was involved in the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II, several
The ETS domain transcription factor ELK1 is in a repressive association with growth genes and is transiently activated through phosphorylation by ERK1/2. In prostate cancer (PCa) cells the androgen receptor (AR) is recruited by ELK1, via its amino-terminal domain (A/B), as a transcriptional...
Within the AR N-terminal domain (NTD) is activation function-1 (AF-1) that is essential for AR transcriptional activity. Inhibitors of AR AF-1 would potentially block most AR mechanisms of resistance including constitutively active AR splice variants that lack the ligand-binding domain. Here we...
Unexpectedly, truncated lungfish MR, consisting of the DNA-binding, hinge and steroid-binding domains, had a stronger response to corticosteroids and progesterone than full-length lungfish MR, indicating that the N-terminal domain represses steroid activation of lungfish MR, unlike human MR in which ...
of H7N7 influenza A virus Meng Hu1, Hin Chu1, Ke Zhang1, Kailash Singh2, Cun Li1, Shuofeng Yuan1, Billy K. C. Chow2, Wenjun Song1, Jie Zhou1 & Bo-Jian Zheng1 The PA N-terminal domain (PA-Nter) is essential for viral transcription and replication. ...
The amino-terminal region of Ack1 is predicted to contain a sterile alpha motif (SAM) domain. SAM domains share a common fold and mediate protein-protein interactions in a wide variety of proteins. Here, we addressed the importance of the Ack1 SAM domain in kinase activity. Results We ...
The invention also encompasses a peptide containing at least one 3-hydroxypyridinium cross-link derived from the C-terminal (carboxy-terminal) telopeptide domain of bone type I collagen. These C-terminal telopeptide sequences are cross-linked with either lysyl pyridinoline or hydroxylysyl pyridinoline....
a(SRA) domain and a RING domain at the C-terminus,[translate] aPHDUHRF1 defines binding specificity of UHRF1 to trimethylated[translate] ashowed that H3K9me3 binding is mediated by the TudorUHRF1[translate] aresidues at its amino terminal portion; it is also devoid[translate]...
Mechanistically, we demonstrate that the truncated Nur77 N-terminal domain protein maintains the stability and activity of hypoxia-inducible factor (HIF)-1, a transcription factor known to regulate bone marrow homeostasis. Additionally, a previously discovered, but uncharacterized, human Nur77 transcript...