The specificity of system y + was shown to be clearly distinct from that of system y + L, a cationic amino acid transporter that accepts neutral amino acids with high affinity in the presence of Na + and which influenced the classical definition of system y + ....
transporter, and in particular the SLC L-typeamino acid transporter1 (LAT1, SLC7A5). This transporter mediates the sodium independent transport of amino acids with large neutral side-chains, such asphenylalanine,methionine,tyrosineandtryptophan. Therefore, radiolabeled variants of these substrates have...
Arginine uptake in mammalian cells is mediated by broad-specificity cationic amino acid transporters26. By contrast, arginine uptake in Leishmania parasites, which are intracellular for a portion of their life cycle, is mediated by a highly selective arginine transporter30, much like TgNPT1-mediated...
During our attempts to crystallise GkApcT, we used a counterflow assay to establish the protein as a relatively broad specificity amino acid transporter with a preference for small hydrophobic and polar amino acids (Fig. 4a). It was surprising, given the high sequence identity to the CATs, ...
Recent findings Gut hormones (e.g. leptin) may regulate intestinal amino acid transporter activity by a variety of mechanisms, although the overall functional significance of such regulation is not yet fully understood. Important functional interactions between amino acid transporters and nutrient-...
Lower eukaryotes such as the yeast Saccharomyces cerevisiae and the filamentous fungus Aspergillus nidulans possess a multiplicity of amino acid transporters or permeases which exhibit different properties with respect to substrate affinity, specificity, capacity and regulation. Regulation of amino acid uptake...
SLC6A14 transport from the endoplasmic reticulum to the cell membrane is aided by the heat shock protein HSP90,a transporter blocker, which can inhibit SLC6A14, and HSP inhibitors can inhibit HSP90 in breast cancer [60]. SLC7A5, also known as neutral amino acid transporter 1 (LAT1), is...
This assay has high sensitivity and excellent specificity for detection of Excitatory Amino Acid Transporter 4 (EAAT4). No significant cross-reactivity or interference between Excitatory Amino Acid Transporter 4 (EAAT4) and analogues was observed. 产品描述 The test principle applied in this kit is...
Specificity of the ELISA Kit for Asc Type Amino Acid Transporter 1 (ASC1) This assay has high sensitivity and excellent specificity for detection of Asc Type Amino Acid Transporter 1 (ASC1). No significant cross-reactivity or interference between Asc Type Amino Acid Transporter 1 (ASC1) and ...
Most of the UMAMIT family proteins analyzed so far are broad specificity amino acid transporters, except for Arabidopsis WAT1, which is a vacuolar auxin transporter17,23. To identify the clades to which the TaUMAMIT proteins belong, a phylogenetic tree including the sequences from six representati...