In this review, we present current information on amino-acid transporters, such as LAT1 (L-leucine transporter), ASCT2 (L-glutamine transporter) and GAT-1 (γ-aminobutyric acid transporter-1), which are critically important for mediating peripheral naive T-cell homeostasis, activation and ...
In contrast, threo-β-hydroxyaspartate (THA) and by L-trans-pyrrolidine-2,4-dicarboxylic acid downregulates this transporter (Arriza et al., 1997). Show abstract Regulation of the Na<sup>+</sup>-coupled glutamate transporter EAAT3 by PIKfyve 2009, Neurochemistry International Show abstract ...
and L-type amino acid transporter 1(LAT1) can also exchange intracellular glutamine with extracellular leucine. In cells, BCAAs are catalyzed to formα-ketoisocaproate (KIC), α-ketoisovalerate (KIV), and α-keto-β-methylvalerate (KMV). The three substances are ...
Verrey F. Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3.J. Biol. Chem. 2009; 284: 19953-19960Abstract Full Text Full Text PDF PubMed Scopus (42) Google Scholar, 5Camargo S.M. Singer D. Makrides V. Huggel K. Pos K.M. Wagner C.A. Kuba K. Danilczyk ...
Unique long 16 binding proteins (ULBPs), otherwise known as retinoic acid early transcripts (RAET) with encoded gene as RAET1, are a family of ligands for NKG2D receptors in humans, which are commonly expressed by tumour cells and facilitate the biological functions of NK cells. Several ...
The gene families for vacuolar amino acid transporters were identified by reverse genetics experiments. In the AVT transporter family, Avt1p works for active uptake of amino acid into vacuole, and Avt3p, Avt4p, and Avt6p for active extrusion of amino acid from vacuole to cytosol. Here, we ...
2012). The activity of the lysosomal proton-assisted amino acid transporter PAT1, responsible for the efflux of amino acids from the lysosomes, may control the concentration of amino acids within the lysosomal lumen and thus the extent of MTORC1 activation (Zoncu et al. 2011), but the ...
Trypanosoma cruzi, the etiological agent of Chagas disease, is auxotrophic for arginine. It obtains this amino acid from the host through transporters expressed on the plasma membrane and on the membranes of intracellular compartments. A few cationic ami
We further investigated the molecular mechanism underlying the activation of DH44+neurons by specific dietary amino acids. By single-cell transcriptome analysis, we identified that CG13248, a putative amino acid transporter, was highly expressed in DH44+neurons and required for dietary amino acids to...
Indeed, another lysosomal membrane-resident, small unbranched amino acid transporter, proton-assisted amino acid transporter 1 (PAT1)/SLC36A1 [88], was previously shown to be important for amino acid-dependent activation of TORC1 in mammals and flies, and interestingly also associates with Rag ...