Following IM administration of a single dose of amikacin of 7.5 mg/kg in adults with normal renal function, peak plasma amikacin concentrations of 17-25 micrograms/mL are attained within 45 minutes to 2 hours.7 Following IV infusion of the same dose given over 1 hour peak plasma concentration...
Amikacin has been used for over 40 years in multidrug resistant tuberculosis (MDR-TB), but there is still debate on the right dose. The aim of this review was to search relevant pharmacokinetic (PK) and pharmacodynamic (PD) literature for the optimal dose and dosing frequency of amikacin in...
Conclusions: As patients with severe sepsis and septic shock have an increased Vd, a first dose of ≥ 25 mg/kg (total body weight) of amikacin is required to reach therapeutic peak concentrations. However, even with this higher amikacin dose, the peak concentration remained below therapeutic ...
Conclusions: As patients with severe sepsis and septic shock have an increased Vd, a first dose of ≥ 25 mg/kg (total body weight) of amikacin is required to reach therapeutic peak concentrations. However, even with this higher amikacin dose, the peak concentration remained below therapeutic ...
The median duration of amikacin treatment was 79.5 days (IQR: 61.75–94) and median total dose of 70.8 g (IQR:44.4–97.75.) 4/31 (12.9%) had moderate-severe baseline hearing loss (HL). A total of 17 (54.8%) patients met the ASHA definition of HL: 7 at 4 kHz, 10 at 6 kHz ...
Cumulative renal excretion of amikacin in 8 hours was 44 per cent of the total dose in bedridden elderly patients and 69 per cent in healthy volunteers. For cephalothin, in seven healthy volunteers, Kel was 0.0353 min1, t was 19.7 min, Vd was 0.176 l./kg; in four bedridden elderly ...
Mean trough and 1 hr postdose serum levels of TB on day 8 of therapy were 1.60±0.8 and 6.6±2 ug/ml, respectively. For AK they were 8.2±3.1 and 27.1±5.2 ug/ml. Neither drug was detected in infant sera 5 days after cessation. Both groups had similar baseline SCr and urine NAG ...
doi:10.1111/j.1651-2227.2004.tb02961.xAmikacinloading dosenosocomial infectionvery low birthweight infantsAim: To develop a simplified amikacin dosage regimen for nosocomial infections in preterm infants including a loading dose in order to achieve therapeutic Maximum Serum Concentrations early in the ...
Mean trough and 1 hr postdose serum levels of TB on day 8 of therapy were 1.60±0.8 and 6.6±2 ug/ml, respectively. For AK they were 8.2±3.1 and 27.1±5.2 ug/ml. Neither drug was detected in infant sera 5 days after cessation. Both groups had similar baseline SCr and urine NAG ...
All patients received fixed dose of intravenous amikacin(500 mg/day) and anti-TB medications for six months. Baseline Pure-Tone Audiometry (PTA) was performed on all patients,before and during the drug treatment with the frequency range between 250 Hz and 8000 Hz. Patients were closely ...