Peak concentrations (30 to 90 minutes after injection) above 35 micrograms per mL and trough concentrations (just prior to the next dose) above 10 micrograms per mL should be avoided. Dosage should be adjusted as indicated. Since the vials are for single-dose only, any unused portion ...
Amikacin crosses the placenta, and concentrations of 0.5–6 mg/L have been found in the cord blood of women receiving 7.5 mg/kg in labor. Concentrations of 8 mg/L and 16.8 mg/L were reached in the fetal lung and kidney, respectively, after a standard dose of 7.5 mg/kg given to healt...
IV15 mg/kg daily given in 3 divided doses.Intrathecal† or Intraventricular†4–20 mg as a single daily dose in conjunction with IM or IV administration of the drug (7.5 mg/kg every 12 hours).Urinary Tract Infections (UTIs)Uncomplicated Infections IV or IM ...
All patients received amikacin at 15 mg/kg per day and had weekly amikacin levels and renal function. Definition of HL was defined as per the ASHA as >20 dB loss of pure tone threshold from baseline at one frequency or >10 dB at two adjacent frequencies.Results31 MDR-TB patients ...
at dose-related incidence and severity, but they were not associated with inflammation, tissuehyperplasia, or the presence of preneoplastic orneoplasticchanges. Dogs were exposed to ARIKAYCE for up to 90 minutes per day, providing inhaled amikacin doses of approximately 5, 10, and 30 mg/kg/day...
Ehrmann S, Mercier E, Vecellio L, Ternant D, Paintaud G, Dequin PF: Pharmacokinetics of high-dose nebulized amikacin in mechanically ventilated healthy subjects. Intensive Care Med 2008, 34: 755-762. 10.1007/s00134-007-0935-1 Article CAS PubMed Google Scholar Pedersen KM, Handlos VN, Hes...
once per day. Information regarding mouse specific aminoglycoside dosing within the literature was limited, so we first assessed a low dose of 40 mg/kg amikacin and steadily increased to 145 mg/kg, which was lethal in mice. We then assessed mice for functional evidence of ototoxicity using the...
Cumulative renal excretion of amikacin in 8 hours was 44 per cent of the total dose in bedridden elderly patients and 69 per cent in healthy volunteers. For cephalothin, in seven healthy volunteers, Kel was 0.0353 min1, t was 19.7 min, Vd was 0.176 l./kg; in four bedridden elderly ...
subjects.Methods: Thirty neonates of gestational age ≥36 weeks and body weight ≥2500 g with suspected or proven sepsis were randomized to receive amikacin either at a dose of 15 mg/kg once per day; group I (n = 15), or a dose of 7·5 mg/kg twice per day, group II (n = 15)...
Thus, the new regimen was set up as follows: 1) 12 mg/kg of AMK every 12 h (i.e. 1,680 mg per day); 2) 10 mg/kg of TCN every 12 h (i.e. 1,400 mg per day) and suppression of the loading dose. Furthermore, both AMK and TCN were to be infused in 20 minutes. This ...