Following injection of an aminoglycoside time must be allowed for the organism to become totally sensitive to readministration. Single dose therapy is then the best suited to P. aeruginosa.doi:10.1016/S0399-077X(05)80979-5DrugeonH.B.Mdecine et Maladies Infectieuses...
94–98% of a single IM or IV dose excreted unchanged by glomerular filtration within 24 hours.Half-life2–3 hours in adults with normal renal function.Special PopulationsIncreased serum concentrations and prolonged half-life in patients with renal impairment. Half-life ranges from 28–86 hours ...
Following IM administration of a single dose of amikacin of 7.5 mg/kg in adults with normal renal function, peak plasma amikacin concentrations of 17-25 micrograms/mL are attained within 45 minutes to 2 hours.7 Following IV infusion of the same dose given over 1 hour peak plasma concentration...
Preliminary intramuscular studies in newborns of different weights (less than 1.5 kg, 1.5 to 2 kg, over 2 kg) at a dose of 7.5 mg/kg revealed that, like other aminoglycosides, serum half-life values were correlated inversely with post-natal age and renal clearances of amikacin. The volume ...
The dose was chosen according to the previous literature on AMK. It is previously reported that AMK single dose for humans with normal renal function ranged from 5 mg/kg/8h to 7.5 mg/kg/12 h (Goutelle et al., 2022; Maxwell et al., 2021; Scholar, 2007; Tally and Gorbach, 1977) fo...
(1.7 and 1.9 h) on the third and seventh days of a period over which 150 mg/m2 was infused over 30 min every 6 h. When the dose was raised to 200 mg/m2 the concentration never fell below 8 mg/L. The plasma half-life was longer in babies of lower birth weight and was still 5...
SD 大鼠体内的药代动力学分析[5] Route Dose (mg/kg) Ka (h-1) Ke1 (h-1) t1/2 (h) V (liter/kg) AUC0-∞ (mg·h/mL) s.c. 100 1.20 6.77 0.10 0.28 53.0 s.c. 500 1.40 1.39 0.50 0.55 649.7 MCE has not independently confirmed the accuracy of these methods. They are for refer...
Cumulative dose and duration of therapy were also significantly higher in the once-daily group. Regimen efficacy (favourable, unfavourable or indeterminate outcome) was assessed by patient temperatures, clinical improvement and white cell counts. Serum creatinine measurements and post-therapy, pure tone ...
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM. In Vivo: Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats...
The most common side effects of ARIKAYCE include: changes in voice and hoarseness (dysphonia), cough during or after a dose of ARIKAYCE, especially in the first month after starting treatment, muscle pain, sore throat, tiredness (fatigue), diarrhea, nausea, headache, fever, decreased weight, ...