Amide Synthesis via a Reactive Acid Chloride IntermediateMettler-Toledo International Inc. all rights reserved
ChemInform Abstract: AMIDE-ACID CHLORIDE ADDUCTS IN ORGANIC SYNTHESIS. PART 12. THE SYNTHESIS OF TRIAZINES FROM N-CYANOCARBAMIMIDATES1,3,5-triazine derivativesdoi:10.1002/chin.198211246R. L. N. HARRISChemischer InformationsdienstRoger L. N. Harris, The Synthesis of Triazines from N-Cyanoamidines...
ChemInform Abstract: AMIDE‐ACID CHLORIDE ADDUCTS IN ORGANIC SYNTHESIS. 7. SELF‐CONDENSATION OF β‐DIALKYLAMINOCROTONATES‐ A SINGLE‐STAGE N,N‐DIALKYLANTHRANILATE SYNTHESIScarboxylic acid esters (benzene compoundsNo abstract is available for this article.doi:10.1002/chin.197645235...
In Fmoc solid-phase peptide synthesis, trifluoracetic acid (TFA) is usually employed to remove the side-chain protecting groups and to cleave peptide from resin. However, the prolonged exposure to acidic conditions and high concentrations of TFA can lead to several side reactions in thioamidated ...
Amines are generally far more nucleophilic than hydroxide ions, so hydrolysis of the acid chloride to give a carboxylic acid is generally not a problem. Note 3. “At the time of my successful synthesis of penicillin V in 1957, I compared the problem of trying to synthesize penicillin by ...
Novel poly(amide-hydrazide)s and copoly(amide-hydrazide)s from bis-(4-aminobenzyl) hydrazide and aromatic diacid chlorides: Synthesis and characterization A new aromatic diamine, viz., bis-(4-aminobenzyl) hydrazide (BABH), which contains preformed hydrazide and methylene linkage, was synthesized sta...
(s, 3H); 13C-NMR The Journal of Antibiotics Total synthesis of amidepsine B T Nagamitsu et al 72 2-Benzyloxy-4-methoxymethoxy-6-methylbenzoic acid (8) To a solution of 7 (0.70 g, 2.45 mmol) in t-BuOH/H2O (1:1) (24.4 ml), 2- methyl-2-butene (1.04 ml, 9.79 mmol), ...
Synthesis of PATCnC 4,4′,4″,4‴-methanetetrayltetrabenzoic acid (4.00 g, 8.06 mmol) was refluxed in thionyl chloride (30 mL, 0.41 mol) at 70 °C for 3 h under N2 until the suspension had become a dark red/brown solution. The excess thionyl chloride was removed...
Substituted β-lactams have recently arisen a lot of interest centered on the synthesis of β-polypeptides (PA3 family),16 which exhibit an important biological activity. Show moreView chapterExplore book Related terms: Imide Carboxamide Lactam Amino Acid Heterocyclic Compound Cyclic Structure Metathesis...
The method demonstrates a wide array of substrates, including amides with typical H/alkyl/aryl substitutions, N,N-disubstituted amides, amides derived from alkyl, aryl, or vinyl carboxylic acids, and even amino acid substrates with stereocentres. Furthermore, we have shown the effectiveness of ...