One of the most important reactions in organic chemistry—amide bond formation—is often overlooked as a contemporary challenge because of the widespread occurrence of amides in modern pharmaceuticals and biologically active compounds. But existing methods are reaching their inherent limits, and concerns ...
Metal-catalyzed amide bond forming reactions in an environmentally friendly aqueousmedium: nitrile hydrations and beyond. García-Alvarez, R.,Crochet, P.,Cadierno, V. Green Chemistry . 2013García-Álvarez R, Crochet P, Cadierno V (2013) Metal-catalyzed amide bond forming reactions in an ...
Despite the amide formation reaction being one of the key cornerstone reactions in organic chemistry, the direct amide formation is both little used and little explored. Acceptance of the feasibility and general applicability of the reaction depends upon the ability of researchers to bring it into th...
This process created branch defects by either amide cleavage or retro-Michael reactions to afford a heterogeneous end-mixture of products affording a wide range of molecular weights (<1500 to >10,000 amu). It was determined that the higher molecular weight components were responsible for ...
The kinetics of the reactions of amide and imide anions 2a-o with benzhydrylium ions 1a-i and structurally related quinone methides 1j-q have been studied by UV-vis spectroscopy in DMSO and acetonitrile solution. The second-order rate constants (log k(2)) correlated linearly with the electroph...
Although enzymes are able to cleave amide bonds in nature, it is difficult to selectively break the carbon–nitrogen bond of an amide using synthetic chemistry; now the activation and cleavage of these bonds using nickel catalysts is used to convert amid
Sulfoxonium ylides are versatile synthons in organic synthesis32,33,34,35. In particular, sulfoxonium ylides are valuable carbene precursors utilized in a variety of reactions, including Johnson–Corey–Chaykovsky cyclopropanation, X–H bond insertions (X = N, O, S, B, halogen), cycloaddition...
In the cases of a β-hydrogen present in a double bond or involved in an aromatic structure, reactions similar to (14.6.17) are not characteristic. A common substituted acetamide is N-phenylacetamide or acetanilide. This compound has applications as an intermediate in various organic syntheses ...
Organic Process & Research Development (“OPRD”) is a great journal for process or scale-up chemistry. This paper shows how the Schotten-Baumann reaction (4 to 3) is preferred for large-scale reactions as it is simple, robust, easily carried out, and does not have large exotherms (unlike...
Coa, Robin A.Canadian Journal of ChemistryBroxton T. J,Cox R. A.Micellar catalysis of organic reactions .part 33.~1 amide hydrolysis in neutral solution in the presence of a copper-containing micelle.Canadian Journal of Chemistry. 1993